Increase in cancer incidence in younger birth cohorts

Bonneux, L., Van Oortmarssen, G., Barendregt, J., Dugdale, A., Adami, H.-O., Sparen, P., Baron, J. and Bergstrom, R. (1993) Increase in cancer incidence in younger birth cohorts. Lancet, 341 8857: 1409-1409. doi:10.1016/0140-6736(93)90974-L

Author Bonneux, L.
Van Oortmarssen, G.
Barendregt, J.
Dugdale, A.
Adami, H.-O.
Sparen, P.
Baron, J.
Bergstrom, R.
Title Increase in cancer incidence in younger birth cohorts
Journal name Lancet   Check publisher's open access policy
ISSN 0140-6736
Publication date 1993-05-01
Sub-type Letter to editor, brief commentary or brief communication
DOI 10.1016/0140-6736(93)90974-L
Open Access Status Not Open Access
Volume 341
Issue 8857
Start page 1409
End page 1409
Total pages 1
Language eng
Abstract Familial cancer risk has been proposed as a shared feature of many cancers, and overall susceptibility is influenced by combinations of low to moderate risk polymorphisms, rare high penetrance germline mutations, and modulation of risk by environmental and genetic factors. Clustering of melanoma occurs in approximately 10 % of families, and an over-representation of additional cancers has been noticed in some 'melanoma' families. The degree to which other cancers aggregate in families affected by melanoma has not been well defined. Therefore, this study aimed to assess the risk of cancers other than melanoma in a cohort of 178 'intermediate risk' melanoma families, not selected for specific genetic mutations. Families designated as 'intermediate risk' had two first degree relatives (FDRs) affected by melanoma when ascertained between 1982 and 1990, and were followed up over a 33 year period to assess new occurrences of cancer. We included 414 melanoma cases and 529 FDRs, comprising 25,264 person years of observation. Standardised incidence ratios and their 95 % confidence intervals were calculated for all invasive cancers, comparing observed to expected cases of cancer based on age and sex specific incidence rates for the Queensland population. Statistically significant increases were found for bladder cancer in females (observed, 7; expected, 1.99; SIR, 3.52; 95 % CI 1.41-7.25), lymphoid leukaemia in females (observed, 6; expected, 1.75; SIR, 3.43; 95 % CI 1.26-7.46), and myeloma in female melanoma cases (observed, 4; expected, 0.82; SIR, 4.89; 95 % CI 1.33-12.52). Over-representation of bladder cancer, lymphoid leukaemia, and myeloma in females of the cohort may suggest sex-dependent co-modifiers, and it is possible that specific combinations of polymorphisms predispose to certain cancer types.
Keyword TRENDS
Q-Index Code CX
Q-Index Status Provisional Code
Institutional Status Unknown

Document type: Journal Article
Sub-type: Letter to editor, brief commentary or brief communication
Collection: School of Public Health Publications
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Created: Thu, 10 Mar 2011, 01:22:12 EST