Airway dendritic cells: Co-ordinators of immunological homeostasis and immunity in the respiratory tract

Stumbles, Philip A., Upham, John W. and Holt, Patrick G. (2003) Airway dendritic cells: Co-ordinators of immunological homeostasis and immunity in the respiratory tract. APMIS, 111 7-8: 741-755. doi:10.1034/j.1600-0463.2003.11107806.x


Author Stumbles, Philip A.
Upham, John W.
Holt, Patrick G.
Title Airway dendritic cells: Co-ordinators of immunological homeostasis and immunity in the respiratory tract
Journal name APMIS   Check publisher's open access policy
ISSN 0903-4641
Publication date 2003-07-01
Sub-type Critical review of research, literature review, critical commentary
DOI 10.1034/j.1600-0463.2003.11107806.x
Volume 111
Issue 7-8
Start page 741
End page 755
Total pages 15
Language eng
Abstract The large quantities and complex mixtures of antigens encountered daily at airway mucosal and alveolar surfaces pose a major challenge to maintenance of immunological homeostasis in the respiratory tract. Amongst this myriad of antigens, the immune system must discriminate between innocuous components that can be tolerated by the host and potentially life-threatening pathogens that require a rapid immune response. Dendritic cells (DC) represent the principal cell type at these sites capable of processing antigens and delivering signals that initiate tolerogenic or immunogenic immune responses. This review will discuss the role of DC at the "front-line" of immune surveillance and homeostasis within the respiratory tract and their role in the pathogenesis of respiratory disease.
Keyword Dendritic cells
Respiratory tract
Tolerance
Immunity
Asthma
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Non-UQ

Document type: Journal Article
Sub-type: Critical review of research, literature review, critical commentary
Collection: School of Medicine Publications
 
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Created: Thu, 10 Mar 2011, 01:17:38 EST