The contribution of toll-like receptors to the pathogenesis of asthma

Phipps, Simon, Lam, Chuan En, Foster, Paul S. and Matthaei, Klaus I. (2007) The contribution of toll-like receptors to the pathogenesis of asthma. Immunology and Cell Biology, 85 6: 463-470. doi:10.1038/sj.icb.7100104


Author Phipps, Simon
Lam, Chuan En
Foster, Paul S.
Matthaei, Klaus I.
Title The contribution of toll-like receptors to the pathogenesis of asthma
Journal name Immunology and Cell Biology   Check publisher's open access policy
ISSN 0818-9641
1440-1711
Publication date 2007-08-01
Year available 2007
Sub-type Critical review of research, literature review, critical commentary
DOI 10.1038/sj.icb.7100104
Open Access Status Not yet assessed
Volume 85
Issue 6
Start page 463
End page 470
Total pages 8
Place of publication London, United Kingdom
Publisher Nature Publishing Group
Language eng
Abstract Asthma is a major disease in the westernized world and its incidence has significantly increased over the past 40 years. Our understanding of the pathogenesis of asthma remains rudimentary, and for this reason, little has been accomplished by way of targeted intervention, either at a population level (to reduce the overall prevalence) or at an individual level (to treat the cause). Instead, the management strategy currently in use relies on broad-spectrum anti-inflammatory agents, generally glucocorticoids and long-acting β2 agonists. The recent discovery of toll-like receptors (TLRs), with their role as the initiators of the innate immune response and inflammation, suggests that modulating these receptors may be beneficial in the treatment of allergic disorders. We review here the cellular distribution of TLR in the lung and their potential contribution to the processes that promote T helper 2 (Th2) immunity and infection-induced exacerbations of allergic lung disease.
Keyword Asthma
Pathogenesis
Toll-like receptors
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Non-UQ
Additional Notes Issue: August/September 2007

Document type: Journal Article
Sub-type: Critical review of research, literature review, critical commentary
Collection: School of Biomedical Sciences Publications
 
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Created: Thu, 10 Mar 2011, 00:31:05 EST