Mechanical ventilation results in diaphragmatic contractile dysfunction

Powers, S. K., Shanely, A., Coombes, J., Ward, K., Demirel, H., Dodd, S., Webb, A., Martin, D. and Cicale, M. (1998). Mechanical ventilation results in diaphragmatic contractile dysfunction. In: -, -, (A417-A417). -.

Author Powers, S. K.
Shanely, A.
Coombes, J.
Ward, K.
Demirel, H.
Dodd, S.
Webb, A.
Martin, D.
Cicale, M.
Title of paper Mechanical ventilation results in diaphragmatic contractile dysfunction
Conference name -
Conference location -
Conference dates -
Journal name FASEB Journal   Check publisher's open access policy
Place of Publication Bethesda, MD, United States
Publisher Federation of American Societies for Experimental Biology
Publication Year 1998
Year available 1998
Sub-type Published abstract
Open Access Status Not Open Access
ISSN 0892-6638
Volume 12
Issue 4
Start page A417
End page A417
Total pages 1
Language eng
Abstract/Summary Recent evidence suggests that prolonged mechanical ventilation (48-260 hours) results in a significant decrease in maximum diaphragmatic force generation in both rats and baboons. These experiments tested the hypothesis that relatively short duration (18 hours) CMV results in a significant depression of diaphragmatic maximal specific force production (specific Po). Adult (female) Sprague Dawley rats were randomly divided into one of two groups: 1) control (CON; n = 6); and 2) 18 hours of controlled mechanical ventilation (CMV; n = 6). Mechanically ventilated animals were anesthetized, intubated, and ventilated with room air. CMV animals were fed enterally with a gastric catheter and arterial blood pressure, pH, and blood gas homeostasis were maintained throughout the 18 hours of mechanical ventilation. Control animals were not anesthetized or mechanically ventilated during the experimental period. Diaphragmatic contractile properties were assessed in vitro at 37oC by analysis of force-frequency characteristics. Eighteen hours of CMV resulted in a significant reduction (P<0.05) in diaphragmatic specific force production at stimulation frequencies ranging from 15 to 160Hz. Compared to CON, mean maximal specific Po (stimulation @ 160 Hz) was 19% lower (P<0.05) in the CMV animals (CON = 26.3 vs. CMV = 21.4 N/cm2). These data indicate that short-term CMV is associated with significant alterations in diaphragmatic contractile function.
Keyword Biochemistry & Molecular Biology
Cell Biology
Biochemistry & Molecular Biology
Life Sciences & Biomedicine - Other Topics
Cell Biology
Q-Index Code EX
Q-Index Status Provisional Code
Institutional Status Unknown

Document type: Conference Paper
Sub-type: Faseb Journal
Collection: School of Human Movement and Nutrition Sciences Publications
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Created: Wed, 09 Mar 2011, 18:54:31 EST