The role of apoptosis in the response of cells and tumours to mild hyperthermia

Harmon, B. V., Takano, Y. S., Winterford, C. M. and Gobe, G. C. (1991) The role of apoptosis in the response of cells and tumours to mild hyperthermia. International Journal of Radiation Biology, 59 2: 489-501. doi:10.1080/09553009114550441

Author Harmon, B. V.
Takano, Y. S.
Winterford, C. M.
Gobe, G. C.
Title The role of apoptosis in the response of cells and tumours to mild hyperthermia
Journal name International Journal of Radiation Biology   Check publisher's open access policy
ISSN 0955-3002
Publication date 1991-02-01
Sub-type Article (original research)
DOI 10.1080/09553009114550441
Open Access Status Not Open Access
Volume 59
Issue 2
Start page 489
End page 501
Total pages 13
Place of publication London, United Kingdom
Publisher Informa Healthcare
Language eng
Abstract There is now abundant evidence that apoptosis, the cell death mechanism responsible for physiologial deletion of cells, can be triggered by mild hyperthermia. However, the overall importance of this mode of death in heated tumours has not yet been established. In this light and electron microscopic study, apoptosis induced by 43°C or 44°C water bath heating for 30 min in a range of murine and human tumours growing in vitro and in four murine tumours growing as solid nodules in vivo, was identified on the basis of its characteristic morphology, and the amount present quantified. Apoptosis was found to play a variable role in the response of tumours to heating, with the lowest levels produced in human melanoma lines (< 1%) and the highest levels in some Burkitt's lymphoma lines (up to 97%). In these latter tumours the induction of apoptosis is clearly a major component of the hyperthermic response.
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collection: School of Medicine Publications
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Citation counts: TR Web of Science Citation Count  Cited 135 times in Thomson Reuters Web of Science Article | Citations
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Created: Wed, 09 Mar 2011, 18:33:15 EST