The vaccination-challenge trial: The gold standard test to evaluate the protective efficacy of infectious coryza vaccines

Garcia, A., Romo, F., Ortiz, A. M. and Blackall, P. J. (2008) The vaccination-challenge trial: The gold standard test to evaluate the protective efficacy of infectious coryza vaccines. Avian Pathology, 37 2: 183-186. doi:10.1080/03079450801929941


Author Garcia, A.
Romo, F.
Ortiz, A. M.
Blackall, P. J.
Title The vaccination-challenge trial: The gold standard test to evaluate the protective efficacy of infectious coryza vaccines
Journal name Avian Pathology   Check publisher's open access policy
ISSN 0307-9457
1465-3338
Publication date 2008-04-01
Sub-type Article (original research)
DOI 10.1080/03079450801929941
Volume 37
Issue 2
Start page 183
End page 186
Total pages 4
Place of publication Colchester, Essex, United Kingdom
Publisher Taylor & Francis
Language eng
Abstract Infectious coryza is an upper respiratory tract disease of chickens with the major impact occurring in multi-age flocks. We investigated the relationship between the level of antibodies, as detected by a haemagglutination-inhibition (HI) assay, in infectious coryza-vaccinated chickens and the protection against challenge in those chickens. In one experiment, chickens given a single dose of either of two infectious coryza vaccines lacked a detectable HI response to vaccination but showed significant levels of protection 11 weeks after vaccination. In contrast, in chickens given two doses of an infectious coryza vaccine and challenged 3 weeks after the second vaccine dose, there was a strong serological response with 36/40 birds having a HI titre of 1/20 or greater. In this trial there was an apparent relationship between titre and subsequent protection, with none of the 32 chickens with a titre of 1/40 or 1/80 showing any clinical signs and only one of the same group yielding the challenge organism on culture. In contrast, three of the four vaccinated chickens with a HI titre less than 1/5 developed the typical clinical signs of coryza and yielded the challenge organism on culture. Overall, our results suggest that HI titres cannot be regarded as a definitive predictor of vaccine efficacy. We suggest that the vaccination-challenge trial is the gold standard for the evaluation of the immune response to infectious coryza vaccines.
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Non-UQ

Document type: Journal Article
Sub-type: Article (original research)
Collection: Queensland Alliance for Agriculture and Food Innovation
 
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Created: Tue, 08 Mar 2011, 00:41:43 EST