Mass transfer and separation criteria for high-speed countercurrent chromatography

Zhao, Chun-Xia and He, Chao-Hong (2011) Mass transfer and separation criteria for high-speed countercurrent chromatography. AIChE Journal, 57 2: 359-372. doi:10.1002/aic.12282


Author Zhao, Chun-Xia
He, Chao-Hong
Title Mass transfer and separation criteria for high-speed countercurrent chromatography
Journal name AIChE Journal   Check publisher's open access policy
ISSN 0001-1541
Publication date 2011-02-01
Year available 2010
Sub-type Article (original research)
DOI 10.1002/aic.12282
Volume 57
Issue 2
Start page 359
End page 372
Total pages 14
Place of publication United States
Publisher John Wiley & Sons
Language eng
Abstract High-speed countercurrent chromatography (HSCCC) is a versatile technique for preparative separations of a wide variety of solutes. For optimization of operating conditions, prediction of separations, and scale-up study, a model is needed to describe the effluent concentration profile, which determines the separation efficiency (mass transfer, mixing, and partitioning) and the resolution between peaks. A transfer-dispersive model is proposed to describe the effluent profile based on the assumption that the retention of a peak is caused by partitioning over two phases, and peak broadening is caused by axial dispersion and mass transfer limitation. In this work, mass transfer was investigated by comparing model simulations to experimental data. One generalized correlation of overall mass transfer coefficients was derived. Based on the correlations of axial dispersion coefficients in our previous work and mass transfer coefficients in this study, the model predicts the elution concentration profile well. Furthermore, separation criteria were proposed to predict the separation of two adjacent solutes, and they were verified using literature data.
Keyword Axial dispersion
High-speed countercurrent chromatography (HSCCC)
Mass transfer
Partition coefficient
Separation criterion
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status Non-UQ
Additional Notes Article first published online: 15 APR 2010

Document type: Journal Article
Sub-type: Article (original research)
Collections: Non HERDC
Australian Institute for Bioengineering and Nanotechnology Publications
 
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Created: Mon, 07 Mar 2011, 21:12:56 EST by Chunxia Zhao on behalf of Aust Institute for Bioengineering & Nanotechnology