KLF1 directly coordinates almost all aspects of terminal erythroid differentiation

Tallack, Michael R. and Perkins, Andrew C. (2010) KLF1 directly coordinates almost all aspects of terminal erythroid differentiation. IUBMB Life, 62 12: 886-890. doi:10.1002/iub.404


Author Tallack, Michael R.
Perkins, Andrew C.
Title KLF1 directly coordinates almost all aspects of terminal erythroid differentiation
Journal name IUBMB Life   Check publisher's open access policy
ISSN 1521-6543
1521-6551
Publication date 2010-12-01
Year available 2015
Sub-type Critical review of research, literature review, critical commentary
DOI 10.1002/iub.404
Open Access Status DOI
Volume 62
Issue 12
Start page 886
End page 890
Total pages 5
Place of publication Oxford, United Kingdom.
Publisher Wiley-Blackwell Publishing
Language eng
Abstract The molecular events and transcriptional mechanisms that underlie erythropoiesis are of great interest to biologists and hematologists since disorders of erythrocytes are common and remain relatively poorly understood. Kruppel-like factor 1 (KLF1) is a critical transcription factor for erythropoiesis in mice and man. Recently the use of chromatin immunoprecipitation (ChIP) coupled to next-generation DNA sequencing (ChIP-seq) has led to an updated understanding of how KLF1 functions in vivo. The full extent of KLF1 target genes have provided new insights into erythropoiesis, and have established that KLF1 controls almost all aspects of erythroid cell development and maturation. (C) 2010 IUBMB IUBMB Life, 62(12): 886-890, 2010
Formatted abstract
The molecular events and transcriptional mechanisms that underlie erythropoiesis are of great interest to biologists and hematologists since disorders of erythrocytes are common and remain relatively poorly understood. Kruppel-like factor 1 (KLF1) is a critical transcription factor for erythropoiesis in mice and man. Recently the use of chromatin immunoprecipitation (ChIP) coupled to next-generation DNA sequencing (ChIP-seq) has led to an updated understanding of how KLF1 functions in vivo. The full extent of KLF1 target genes have provided new insights into erythropoiesis, and have established that KLF1 controls almost all aspects of erythroid cell development and maturation. © 2010 IUBMB IUBMB Life, 62(12): 886–890
Keyword Transcriptional regulation
Transcription factors
Thalassemia
Hemoglobin
Erythrocytes
Apoptosis
Iron
Q-Index Code C1
Q-Index Status Confirmed Code
Grant ID APP1030143
Institutional Status UQ

Document type: Journal Article
Sub-type: Critical review of research, literature review, critical commentary
Collections: Official 2011 Collection
Institute for Molecular Bioscience - Publications
 
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Created: Sun, 06 Mar 2011, 10:11:14 EST