Baculovirus kinetics, insect cell culture

Chan, Leslie, Reid, Steven and Nielsen, Lars Keld (2010). Baculovirus kinetics, insect cell culture. In Michael C. Flickinger (Ed.), Encyclopedia of industrial biotechnology: Bioprocess, bioseparation, and cell technology (pp. 1-24) Hoboken, N.J. USA: John Wiley and Sons Inc.. doi:10.1002/9780470054581

Author Chan, Leslie
Reid, Steven
Nielsen, Lars Keld
Title of chapter Baculovirus kinetics, insect cell culture
Title of book Encyclopedia of industrial biotechnology: Bioprocess, bioseparation, and cell technology
Place of Publication Hoboken, N.J. USA
Publisher John Wiley and Sons Inc.
Publication Year 2010
Sub-type Research book chapter (original research)
DOI 10.1002/9780470054581
Year available 2010
ISBN 0470054581
Editor Michael C. Flickinger
Start page 1
End page 24
Total pages 25
Total chapters 360
Collection year 2011
Language eng
Formatted Abstract/Summary
Viral-based processes continue to represent an important class of cell culture processes. Indeed, the number of viral-based cell culture processes is increasing with (a) viral vaccine production moving from primary cells to continuous cell lines, (b) increased use of viral biopesticides, (c) increased use of viral expression systems, and (d) the use of viral gene therapy vectors. The inherent complexity combined with the problems of working with human or animal pathogens has meant that the academic treatment of viral production kinetics has lagged behind that of other cell culture systems. The emergence of the baculovirus (an innocuous insect virus) for protein expression changed this situation and the baculovirus is used throughout this article to illustrate how to handle complex viral kinetics. Emphasis is placed on the development of mathematical models, which are essential tools when studying viral production kinetics.
Keyword Baculovirus
Synchronous infection
Cell yield
Kinetic model
Virus titer
Q-Index Code BX
Q-Index Status Confirmed Code
Institutional Status UQ
Additional Notes Published Online: 15 APR 2010; Description: 7 v. (xxvii, 5051 p.) : ill. ; 29 cm.

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Created: Thu, 03 Mar 2011, 11:17:23 EST by Melanie Gibbons on behalf of Aust Institute for Bioengineering & Nanotechnology