Effect based monitoring of seasonal ambient air exposures in Australia sampled by PUF passive air samplers

Kennedy, Karen, Macova, Miroslava, Bartkow, Michael E., Hawker, Darryl W., Zhao, Bin, Denison, Michael S. and Mueller, Jochen F. (2010) Effect based monitoring of seasonal ambient air exposures in Australia sampled by PUF passive air samplers. Atmospheric Pollution Research, 1 1: 50-58. doi:10.5094/APR.2010.008


Author Kennedy, Karen
Macova, Miroslava
Bartkow, Michael E.
Hawker, Darryl W.
Zhao, Bin
Denison, Michael S.
Mueller, Jochen F.
Title Effect based monitoring of seasonal ambient air exposures in Australia sampled by PUF passive air samplers
Journal name Atmospheric Pollution Research   Check publisher's open access policy
ISSN 1309-1042
Publication date 2010-01-01
Sub-type Article (original research)
DOI 10.5094/APR.2010.008
Open Access Status DOI
Volume 1
Issue 1
Start page 50
End page 58
Total pages 9
Place of publication Turkey
Publisher Dokuz Eylul Universitesi * Department of Environmental Engineering
Language eng
Abstract There has been relatively little bioanalytical effect based monitoring conducted using samples derived from polyurethane foam (PUF) passive air samplers. Combining these techniques may provide a more convenient and cost effective means of monitoring the potential for biological effects resulting from exposure to complex mixtures in a range of scenarios. Seasonal polycyclic aromatic hydrocarbon (PAH) levels were monitored at sites around Australia using direct chemical analysis. In addition, both indirect acting genotoxicity (umuC assay) and aryl hydrocarbon receptor (AhR) activity (chemically activated fluorescent gene expression [CAFLUX assay]), which are effects potentially relevant to subsequent carcinogenesis for these compounds, were measured. The levels of PAHs as well as genotoxicity and AhR activity were all higher in winter compared to summer and for sites in urban capital cities compared to other locations. Statistically significant relationships were found between the levels of PAHs and both genotoxicity and AhR activity. The dominant contributors to the total AhR activity, were found to be for compounds which are not resistant to H2SO4/silica gel treatment and were relatively rapidly metabolised that is consistent with a PAH type response. Relative potency estimates for individual PAHs determined for the first time on the CAFLUX assay were used to estimate the proportion of total AhR activity (≤ 3.0%) accounted by PAHs monitored. Observed responses are thus largely due to non‐quantified AhR active compounds.
Keyword Passive air sampling
Polyurethane foam (PUF)
Polycyclic aromatic hydrocarbons
Aryl hydrocarbon receptor activity
Genotoxicity
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: Official 2011 Collection
National Research Centre for Environmental Toxicology Publications
 
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Citation counts: TR Web of Science Citation Count  Cited 13 times in Thomson Reuters Web of Science Article | Citations
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Created: Wed, 02 Mar 2011, 23:52:53 EST by Mrs Karen Kennedy on behalf of National Res Centre For Environmental Toxicology