Immunohistochemical Distribution of Laminin-332 and Collagen Type IV in the Basement Membrane of Normal Horses and Horses with Induced Laminitis

Visser, M.B. and Pollitt, C. C. (2011) Immunohistochemical Distribution of Laminin-332 and Collagen Type IV in the Basement Membrane of Normal Horses and Horses with Induced Laminitis. Journal of Comparative Pathology, 145 1: 80-87. doi:10.1016/j.jcpa.2010.11.009


Author Visser, M.B.
Pollitt, C. C.
Title Immunohistochemical Distribution of Laminin-332 and Collagen Type IV in the Basement Membrane of Normal Horses and Horses with Induced Laminitis
Journal name Journal of Comparative Pathology   Check publisher's open access policy
ISSN 0021-9975
1532-3129
Publication date 2011-07-01
Sub-type Article (original research)
DOI 10.1016/j.jcpa.2010.11.009
Volume 145
Issue 1
Start page 80
End page 87
Total pages 8
Place of publication Oxford, United Kingdom
Publisher Elsevier
Language eng
Abstract The basement membrane (BM) is a thin layer of extracellular matrix that regulates cell functions as well as providing support to tissues of the body. Primary components of the BM of epithelial tissues are laminin-332 (Ln-332) and collagen type IV. Equine laminitis is a disease characterized by destruction and dislocation of the hoof lamellar BM. Immunohistochemistry was used to characterize the distribution of Ln-332 and collagen type IV in the organs of normal horses and these proteins were found to be widespread. Analysis of a panel of tissue samples from horses with experimentally-induced laminitis revealed that Ln-332 and collagen type IV degradation occurs in the skin and stomach in addition to the hoof lamellae. These findings suggest that BM degradation is common to many epithelial tissues during equine laminitis and suggests a role for systemic trigger factors in this disease. Crown Copyright © 2010.
Keyword Collagen type IV
Horse
Laminin-332
Laminitis
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ
Additional Notes Available online 17 January 2011.

Document type: Journal Article
Sub-type: Article (original research)
Collections: Official 2012 Collection
School of Veterinary Science Publications
 
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Created: Wed, 02 Mar 2011, 03:31:35 EST by Professor Christopher Pollitt on behalf of School of Veterinary Science