Antimicrobial and cytotoxic activities of synthetically derived tambjamines C and E-J, BE-18591, and a related alkaloid from the marine bacterium Pseudoalteromonas tunicata

Pinkerton, David M., Banwell, Martin G., Garson, Mary J., Kumar, Naresh, Odorico de Moraes, Manoel, Cavalcanti, Bruno C., Barros, Francisco W. A. and Pessoa, Cláudia (2010) Antimicrobial and cytotoxic activities of synthetically derived tambjamines C and E-J, BE-18591, and a related alkaloid from the marine bacterium Pseudoalteromonas tunicata. Chemistry and Biodiversity, 7 5: 1311-1324. doi:10.1002/cbdv.201000030


Author Pinkerton, David M.
Banwell, Martin G.
Garson, Mary J.
Kumar, Naresh
Odorico de Moraes, Manoel
Cavalcanti, Bruno C.
Barros, Francisco W. A.
Pessoa, Cláudia
Title Antimicrobial and cytotoxic activities of synthetically derived tambjamines C and E-J, BE-18591, and a related alkaloid from the marine bacterium Pseudoalteromonas tunicata
Formatted title
Antimicrobial and cytotoxic activities of synthetically derived tambjamines C and E-J, BE-18591, and a related alkaloid from the marine bacterium Pseudoalteromonas tunicata
Journal name Chemistry and Biodiversity   Check publisher's open access policy
ISSN 1612-1872
Publication date 2010-05-01
Sub-type Article (original research)
DOI 10.1002/cbdv.201000030
Volume 7
Issue 5
Start page 1311
End page 1324
Total pages 24
Place of publication Germany
Publisher Wiley - VCH Verlag GmbH & Co. KGaA
Language eng
Abstract In the first comprehensive biological assessment of the tambjamine class of marine alkaloids, synthetically derived samples of compounds 1-9 have been subjected to evaluation as antimicrobial agents and screened for their cytotoxic effects on various human cancer cell lines. Most were strongly active against the fungus Malassezia furfur (>amphotericin B) and showed considerable, but non-selective, antiproliferative activity against both human cancer and normal cell lines. Tambjamines I and J (6 and 7, resp.) displayed significant apoptosis-inducing effects. © 2010 Verlag Helvetica Chimica Acta AG.
Keyword 4-Methoxypyrrolic natural-products
Ascidian atapozoa Sp
Nudibranch predators
Therapeutic agents
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ
Additional Notes Special Issue: Systems Biology in the Microbial World and Beyond

Document type: Journal Article
Sub-type: Article (original research)
Collections: Official 2011 Collection
School of Chemistry and Molecular Biosciences
 
Versions
Version Filter Type
Citation counts: TR Web of Science Citation Count  Cited 20 times in Thomson Reuters Web of Science Article | Citations
Scopus Citation Count Cited 21 times in Scopus Article | Citations
Google Scholar Search Google Scholar
Created: Mon, 28 Feb 2011, 22:17:44 EST by Jennifer Falknau on behalf of School of Chemistry & Molecular Biosciences