The effects of GC Tooth Mousse on cervical dentinal sensitivity: A controlled clinical trial

Walsh, Laurence J. (2010) The effects of GC Tooth Mousse on cervical dentinal sensitivity: A controlled clinical trial. International Dentistry South Africa, 12 1: 4-12.

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Author Walsh, Laurence J.
Title The effects of GC Tooth Mousse on cervical dentinal sensitivity: A controlled clinical trial
Journal name International Dentistry South Africa
ISSN 1818-6734
Publication date 2010-01
Sub-type Article (original research)
Volume 12
Issue 1
Start page 4
End page 12
Total pages 6
Editor Marco Ferrari
Place of publication Wendywood, S.A.
Publisher Modern Dentistry Media
Collection year 2011
Language eng
Formatted abstract
Purpose: The clinical problem of cervical dentinal hypersensitivity (CDS) can be managed by strategies that occlude patent dentine tubules exposed to the oral environment, or that reduce the excitability of pulpal nerves.

Materials and methods: This randomized clinical trial with 89 subjects (53 from private practice and 36 from public sector dental clinics) compared the therapeutic effect of a 10% CPP-ACP crème (GC Tooth Mousse) applied topically each night before retiring in conjunction with a conventional dentifrice twice daily, to the twice daily use of an established potassium nitrate dentifrice (Colgate Sensitive). Treatments were used over 6 weeks, and this was followed by a 4 week washout period. CDS responses to 4 types of stimuli were self-rated using a visual-analogue scale at 4, 6, and 10 weeks, and a composite CDS score calculated. All data were analyzed in a blinded manner.

Results: The two treatment groups were well matched with no significance difference in baseline scores. In both the CPP-ACP and potassium nitrate groups, when compared with their relevant baseline values, CDS scores were reduced significantly at 4 weeks when assessed using a repeated measures ANOVA (P<0.02). This effect was sustained at 6 weeks, and across the ensuing 4 week washout period. At all time points, there was no significant difference between the two treatment groups. The reduction in CDS scores was more pronounced in public sector dental patients than in those drawn from private practice.

Conclusions: Despite differences in their apparent mechanisms of action, both CPP-ACP crème and the potassium nitrate dentifrice gave similar clinically useful reductions in CDS.
Keyword CPP-ACP
Tooth Mousse
Potassium nitrate
Dentine sensitivity
Clinical trial
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ
Additional Notes Publication date: January/February 2010

Document type: Journal Article
Sub-type: Article (original research)
Collections: Official 2011 Collection
School of Dentistry Publications
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Created: Fri, 25 Feb 2011, 14:27:44 EST by Margot Dallinger on behalf of School of Dentistry