Genome-wide meta-analysis increases to 71 the number of confirmed Crohn’s disease susceptibility loci

Franke, Andre, McGoven, Demot P. B., Barrett,Jeffrey C., Wangs, Kai, Radford-Smith, Graham L., Ahmad, Tariq, Lees, Charlie W., Balschun, Tobias, Lee, James, Roberts, Rebecca, Anderson, Carl A., Bis, Joshua C., Bumpstead,Suzanne, Ellinghaus, David, Festen, Eleonora M., Georges, Michel, Green, Todd, Haritunians, Talin, Jostinm, Luke, Latiano, Anna, Mathew, Christopher G., Montgomery, Grant, Prescott, Natalie J., Raychaudhuri, Soumya, Rotter.Jerome I., Schumm, Philip, Sharma,Yashoda, Simms, Lisa A., Taylor, Kent D,, Whiteman, David, Wijmenga, Cisca, Baldassano, Robert N., Barclay, Murray, Bayless. Theodore M., Brand, Stephan, Buning, Carsten, Cohen, Albert, Colombel, Jean-Frederick, Cottone, Mario, Stronati, Laura, Denson, Ted, De Vos, Martine, D'Inca, Renata, Dubinsky. Marla, Edwards, Cathryn, Florin, Tim, Franchimont, Denis, Gearry, Richard, Glas, Jurgen, Van Gossum, Andre, Guthery, Stephen L., Halfvarson, Jonas, Verspaget, Hein W., Hugot, Jean-Pierre, Karban, Amir, Laukens, Debby, Lawrance, Ian, Lemann, Marc, Levine, Arie, Libioulle, Cecile, Louis, Edouard, Mowat, Craig, Newman, William, Panes, Julian, Phillips. Anne, Proctor, Deborah D., Regueiro, Miguel, Russell , Richard, Rutgeerts, Paul, Sanderson, Jeremy, Sans, Miquel, Seibold, Frank, Steinhart, A. Hillary, Stokkers, Pieter C. F., Torkvist, Leif, Kullak-Ublick, Gerd, Wilson, David, Walters, Thomas, Targan,Stephan R., Brant, Steven R., Rioux, John D., D'Amato, Mauro, Weersma, Rinse K., Kugathasan, Subra, Griffiths, Anne M., Mansfield, John C., Vermeire, Severine, Duerr, Richard H., Silverberg, Mark S., Satsangi, Jack, Schreiber, Stefan, Cho, Judy H., Annese, Vito, Hakonarson, Hakon, Daly, Mark J. and Parkes, Miles P (2010) Genome-wide meta-analysis increases to 71 the number of confirmed Crohn’s disease susceptibility loci. Nature Genetics, 42 12: 1118-1125. doi:10.1038/ng.717

Author Franke, Andre
McGoven, Demot P. B.
Barrett,Jeffrey C.
Wangs, Kai
Radford-Smith, Graham L.
Ahmad, Tariq
Lees, Charlie W.
Balschun, Tobias
Lee, James
Roberts, Rebecca
Anderson, Carl A.
Bis, Joshua C.
Ellinghaus, David
Festen, Eleonora M.
Georges, Michel
Green, Todd
Haritunians, Talin
Jostinm, Luke
Latiano, Anna
Mathew, Christopher G.
Montgomery, Grant
Prescott, Natalie J.
Raychaudhuri, Soumya
Rotter.Jerome I.
Schumm, Philip
Simms, Lisa A.
Taylor, Kent D,
Whiteman, David
Wijmenga, Cisca
Baldassano, Robert N.
Barclay, Murray
Bayless. Theodore M.
Brand, Stephan
Buning, Carsten
Cohen, Albert
Colombel, Jean-Frederick
Cottone, Mario
Stronati, Laura
Denson, Ted
De Vos, Martine
D'Inca, Renata
Dubinsky. Marla
Edwards, Cathryn
Florin, Tim
Franchimont, Denis
Gearry, Richard
Glas, Jurgen
Van Gossum, Andre
Guthery, Stephen L.
Halfvarson, Jonas
Verspaget, Hein W.
Hugot, Jean-Pierre
Karban, Amir
Laukens, Debby
Lawrance, Ian
Lemann, Marc
Levine, Arie
Libioulle, Cecile
Louis, Edouard
Mowat, Craig
Newman, William
Panes, Julian
Phillips. Anne
Proctor, Deborah D.
Regueiro, Miguel
Russell , Richard
Rutgeerts, Paul
Sanderson, Jeremy
Sans, Miquel
Seibold, Frank
Steinhart, A. Hillary
Stokkers, Pieter C. F.
Torkvist, Leif
Kullak-Ublick, Gerd
Wilson, David
Walters, Thomas
Targan,Stephan R.
Brant, Steven R.
Rioux, John D.
D'Amato, Mauro
Weersma, Rinse K.
Kugathasan, Subra
Griffiths, Anne M.
Mansfield, John C.
Vermeire, Severine
Duerr, Richard H.
Silverberg, Mark S.
Satsangi, Jack
Schreiber, Stefan
Cho, Judy H.
Annese, Vito
Hakonarson, Hakon
Daly, Mark J.
Parkes, Miles P
Title Genome-wide meta-analysis increases to 71 the number of confirmed Crohn’s disease susceptibility loci
Journal name Nature Genetics   Check publisher's open access policy
ISSN 1061-4036
Publication date 2010-12-01
Sub-type Article (original research)
DOI 10.1038/ng.717
Volume 42
Issue 12
Start page 1118
End page 1125
Total pages 8
Place of publication New York, NY, U.S.A.
Publisher Nature Publishing Group
Language eng
Formatted abstract
We undertook a meta-analysis of six Crohn's disease genome-wide association studies (GWAS) comprising 6,333 affected individuals (cases) and 15,056 controls and followed up the top association signals in 15,694 cases, 14,026 controls and 414 parent-offspring trios. We identified 30 new susceptibility loci meeting genome-wide significance (P < 5 × 10 -8). A series of in silico analyses highlighted particular genes within these loci and, together with manual curation, implicated functionally interesting candidate genes including SMAD3, ERAP2, IL10, IL2RA, TYK2, FUT2, DNMT3A, DENND1B, BACH2 and TAGAP. Combined with previously confirmed loci, these results identify 71 distinct loci with genome-wide significant evidence for association with Crohn's disease.

Keyword Inflammatory-bowel-disease
Sequence variants
Common variants
Nedd4 family
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status Non-UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: Non HERDC
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Created: Fri, 25 Feb 2011, 18:40:19 EST by Debbie Banks on behalf of School of Medicine