Host immunity as a determinant of treatment outcome in Plasmodium falciparum malaria

Rogerson, Stephen J., Wijesinghe, Rushika S. and Meshnick, Steven R. (2010) Host immunity as a determinant of treatment outcome in Plasmodium falciparum malaria. Lancet Infectious Diseases, 10 1: 51-59. doi:10.1016/S1473-3099(09)70322-6


Author Rogerson, Stephen J.
Wijesinghe, Rushika S.
Meshnick, Steven R.
Title Host immunity as a determinant of treatment outcome in Plasmodium falciparum malaria
Journal name Lancet Infectious Diseases   Check publisher's open access policy
ISSN 1473-3099
Publication date 2010-01-01
Sub-type Article (original research)
DOI 10.1016/S1473-3099(09)70322-6
Volume 10
Issue 1
Start page 51
End page 59
Total pages 9
Place of publication United Kingdom
Publisher The Lancet Publishing Group
Collection year 2011
Language eng
Abstract Host immunity is an important but poorly understood determinant of antimalarial efficacy, influencing the outcome of prevention and treatment trials. Variations in host immunity might explain why factors such as host genetics, age, pregnancy, infection with HIV, parasite density, and malaria transmission intensity, can raise or lower apparent cure rates. Recently, attempts have been made to characterise immunological correlates of treatment outcome in Plasmodium falciparum malaria, but not yet for Plasmodium vivax. A better understanding of such correlates might improve trials of antimalarial drugs and provide leads for vaccine development. Greater understanding of the relation between host immunity and treatment outcome is crucial to making informed choices about the use of safe but partly effective drugs for malaria prevention in children and pregnant women. With increasing malaria control efforts worldwide, declining population immunity might alter drug response profiles. Improved methods for assessing antimalarial immunity will strengthen malaria control efforts. © 2010 Elsevier Ltd. All rights reserved.
Keyword Aging
Antimalarials
Female
Humans
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status Non-UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: Non HERDC
School of Public Health Publications
 
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Created: Tue, 22 Feb 2011, 00:48:05 EST by Geraldine Fitzgerald on behalf of School of Public Health