Developmental motifs reveal complex structure in cell lineages

Geard, Nicholas, Bullock, Seth, Lohaus, Rolf, Azevedo, Ricardo B. R. and Wiles, Janet (2011) Developmental motifs reveal complex structure in cell lineages. Complexity, 16 4: 48-57. doi:10.1002/cplx.20341


Author Geard, Nicholas
Bullock, Seth
Lohaus, Rolf
Azevedo, Ricardo B. R.
Wiles, Janet
Title Developmental motifs reveal complex structure in cell lineages
Journal name Complexity   Check publisher's open access policy
ISSN 1099-0526
1076-2787
Publication date 2011-03-01
Year available 2010
Sub-type Article (original research)
DOI 10.1002/cplx.20341
Volume 16
Issue 4
Start page 48
End page 57
Total pages 10
Place of publication Hoboken, NJ, United States
Publisher John Wiley & Sons
Language eng
Formatted abstract
Many natural and technological systems are complex, with organizational structures that exhibit characteristic patterns but defy concise description. One effective approach to analyzing such systems is in terms of repeated topological motifs. Here, we extend the motif concept to characterize the dynamic behavior of complex systems by introducing developmental motifs, which capture patterns of system growth. As a proof of concept, we use developmental motifs to analyze the developmental cell lineage of the nematode Caenorhabditis elegans, revealing a new perspective on its complex structure. We use a family of computational models to explore how biases arising from the dynamics of the developmental gene network, as well as spatial and temporal constraints acting on development, contribute to this complex organization.
Keyword Cell lineages
Development
Gene regulatory networks
Generative bias
Motifs
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ
Additional Notes Published online: 17 August, 2010.

Document type: Journal Article
Sub-type: Article (original research)
Collections: Official 2012 Collection
School of Information Technology and Electrical Engineering Publications
 
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Created: Thu, 17 Feb 2011, 23:34:01 EST by Janet Wiles on behalf of School of Information Technol and Elec Engineering