Morphine and tumor growth and metastasis

Afsharimani, Banafsheh, Cabot, Peter and Parat, Marie-Odile (2011) Morphine and tumor growth and metastasis. Cancer and Metastasis Reviews, 30 2: 225-238. doi:10.1007/s10555-011-9285-0

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Author Afsharimani, Banafsheh
Cabot, Peter
Parat, Marie-Odile
Title Morphine and tumor growth and metastasis
Journal name Cancer and Metastasis Reviews   Check publisher's open access policy
ISSN 0167-7659
Publication date 2011-06-01
Year available 2011
Sub-type Article (original research)
DOI 10.1007/s10555-011-9285-0
Open Access Status Not Open Access
Volume 30
Issue 2
Start page 225
End page 238
Total pages 14
Place of publication New York, NY, United States
Publisher Springer New York
Language eng
Abstract Morphine is an analgesic widely used to alleviate cancer pain. In addition, the perioperative management of pain in cancer surgery patients most often includes opioids. However, there are reports that these drugs may alter cancer recurrence or metastasis. Several mechanisms have been proposed, such as the modulation of the immune response or cellular pathways that control the survival and migratory behavior of cancer cells. The published literature, however, presents some discrepancies, with reports suggesting that opioids may either promote or prevent the spread of cancer. It is of great importance to determine whether opioids, in particular the most widely used, morphine, may increase the risk of metastasis when used in cancer surgery. This review examines the available data on the effects of morphine which influence cancer metastasis or recurrence, including immunomodulation, tumor cell aggressiveness, and angiogenesis, with special emphasis on recently published clinical and laboratory based studies. We further discuss the parameters that may explain the difference between reports on the effects of morphine on cancer.
Keyword Invasion
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ
Additional Notes Non-Thematic Review

Document type: Journal Article
Sub-type: Article (original research)
Collections: Official 2012 Collection
School of Pharmacy Publications
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Citation counts: TR Web of Science Citation Count  Cited 66 times in Thomson Reuters Web of Science Article | Citations
Scopus Citation Count Cited 79 times in Scopus Article | Citations
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Created: Tue, 15 Feb 2011, 22:25:54 EST by Charna Kovacevic on behalf of School of Pharmacy