Testis-like steroidogenesis in the ovotestis of the European mole, Talpa europaea

Whitworth, Deanne J., Licht, Paul, Racey, Paul A. and Glickman, Stephen E. (1999) Testis-like steroidogenesis in the ovotestis of the European mole, Talpa europaea. Biology of Reproduction, 60 2: 413-418. doi:10.1095/biolreprod60.2.413


Author Whitworth, Deanne J.
Licht, Paul
Racey, Paul A.
Glickman, Stephen E.
Title Testis-like steroidogenesis in the ovotestis of the European mole, Talpa europaea
Formatted title
Testis-like steroidogenesis in the ovotestis of the European mole, Talpa europaea
Journal name Biology of Reproduction   Check publisher's open access policy
ISSN 0006-3363
1529-7268
Publication date 1999-02-01
Sub-type Article (original research)
DOI 10.1095/biolreprod60.2.413
Volume 60
Issue 2
Start page 413
End page 418
Total pages 6
Place of publication Madison, WI, United States
Publisher Society for the Study of Reproduction
Language eng
Formatted abstract
The female European mole (Talpa europaea) presents a vivid paradox in relation to our contemporary understanding of mammalian sexual differentiation. These animals are exceptional among female mammals in that they possess bilateral ovotestes. The ovotestis contains a morphologically normal ovarian component that develops during the spring breeding season and a histologically defined testicular region, the interstitial gland, which enlarges during autumn when the ovarian component decreases in size. In correlation with this unusual gonadal situation, the female mole displays a penile clitoris traversed by a urethral canal. Although the histology of the ovotestis is well documented and has recently been extended to an additional three species of the genus Talpa, there have been no clear indications of the physiological function, particularly androgen production, of the ovotestis in these female moles. This paper presents the first clear evidence of seasonal variation in plasma testosterone concentrations, which parallel the growth and regression of the 'testicular' interstitial gland, in T. europaea. Plasma androstenedione did not show significant seasonal variation, but plasma testosterone (1.06 ± 0.2 ng/ml) and gonadal testosterone concentration (1.57 ± 0.65 μg/mg protein) in females in autumn were significantly higher (p < 0.02) than plasma (0.4 ± 0.2 ng/ml) and gonadal (0.24 ± 0.21 μg/mg) concentrations in pregnant or immediately postpartum females in spring. Our data also reveal selective metabolic production of testosterone from radiolabeled steroid precursors (progesterone and androstenedione) by these ovarian interstitial tissues and male testes; estradiol is produced by ovarian tissue but not interstitial gland or testis.
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Unknown

Document type: Journal Article
Sub-type: Article (original research)
Collection: School of Veterinary Science Publications
 
Versions
Version Filter Type
Citation counts: TR Web of Science Citation Count  Cited 23 times in Thomson Reuters Web of Science Article | Citations
Scopus Citation Count Cited 24 times in Scopus Article | Citations
Google Scholar Search Google Scholar
Created: Wed, 09 Feb 2011, 21:41:50 EST by Dr Deanne Whitworth on behalf of School of Veterinary Science