Role of autoreactivity against myelin proteolipid protein in multiple sclerosis

Greer, Judith, Csurhes, Peter, Muller, Diane and Pender, Michael (2008). Role of autoreactivity against myelin proteolipid protein in multiple sclerosis. In: 9th International Congress of Neuroimmunology: Abstracts. From basic to clinical neuroimmunology: An introductory course. ISNI 2008: 9th International Congress of Neuroimmunology, Fort Worth, TX, U.S.A., (212-213). October 26-30, 2008. doi:10.1016/j.jneuroim.2008.08.001


Author Greer, Judith
Csurhes, Peter
Muller, Diane
Pender, Michael
Title of paper Role of autoreactivity against myelin proteolipid protein in multiple sclerosis
Conference name ISNI 2008: 9th International Congress of Neuroimmunology
Conference location Fort Worth, TX, U.S.A.
Conference dates October 26-30, 2008
Convener International Society of Neuroimmunology
Proceedings title 9th International Congress of Neuroimmunology: Abstracts. From basic to clinical neuroimmunology: An introductory course   Check publisher's open access policy
Journal name Journal of Neuroimmunology   Check publisher's open access policy
Place of Publication Amsterdam, Netherlands
Publisher Elsevier
Publication Year 2008
Year available 2008
Sub-type Published abstract
DOI 10.1016/j.jneuroim.2008.08.001
Open Access Status Not yet assessed
ISSN 0165-5728
1872-8421
Volume 203
Issue 2
Start page 212
End page 213
Total pages 2
Language eng
Formatted Abstract/Summary
We have previously shown that T cell autoreactivity directed against epitopes in the second extracellular loop of myelin proteolipid protein (PLP) correlates strongly with the development of brainstem and cerebellar lesions in multiple sclerosis (MS) patients and in an animal model of MS. PLP is present throughout compact myelin and on the external face of the myelin membrane, and the second extracellular loop would therefore potentially be accessible to antibody. In the current study, we investigate the putative functional properties of auto-antibodies directed against the same region of PLP, and the role that they play in lesion localization.

The results strongly suggest that PLP-specific antibodies could be of functional relevance in the pathogenesis of MS.
Subjects 320207 Autoimmunity
300504 Immunology
Keyword Immunology
Neurosciences
Immunology
Neurosciences & Neurology
IMMUNOLOGY
NEUROSCIENCES
Q-Index Code EX
Q-Index Status Provisional Code
Institutional Status UQ
Additional Notes Presented during the Workshop: "MS immune studies" as Paper 1.

Document type: Conference Paper
Sub-type: Published abstract
Collection: School of Medicine Publications
 
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Created: Thu, 03 Feb 2011, 21:29:28 EST by Mr Peter Csurhes on behalf of Medicine - Royal Brisbane and Women's Hospital