Infection with specific strains of Epstein-Barr virus are a risk factor for multiple sclerosis

Brennan, Rebekah M., Burrows, Jacqueline M., Bell, Melissa J., Lenarczyk, Aleksandra, Csurhes, Peter A., Pender, Michael. and Burrows, Scott R. (2008). Infection with specific strains of Epstein-Barr virus are a risk factor for multiple sclerosis. In: Abstracts. Joint World Congress on Treatment and Research in Multiple Sclerosis: 13th Annnual Meeting of the Americas Committee for Treatment and Research in Multiple Sclerosis / 24th Congress of the European Committee for Treatment and Research in Multiple Sclerosis / 5th Congress of the Latin American Committee for Treatment and Research in Multiple Sclerosis, Montréal, QC, Canada, (S60-S60). 17-20 September 2008. doi:10.1177/1352458508096399


Author Brennan, Rebekah M.
Burrows, Jacqueline M.
Bell, Melissa J.
Lenarczyk, Aleksandra
Csurhes, Peter A.
Pender, Michael.
Burrows, Scott R.
Title of paper Infection with specific strains of Epstein-Barr virus are a risk factor for multiple sclerosis
Conference name Joint World Congress on Treatment and Research in Multiple Sclerosis: 13th Annnual Meeting of the Americas Committee for Treatment and Research in Multiple Sclerosis / 24th Congress of the European Committee for Treatment and Research in Multiple Sclerosis / 5th Congress of the Latin American Committee for Treatment and Research in Multiple Sclerosis
Conference location Montréal, QC, Canada
Conference dates 17-20 September 2008
Proceedings title Abstracts   Check publisher's open access policy
Journal name Multiple Sclerosis   Check publisher's open access policy
Place of Publication London, U.K.
Publisher Sage Publications
Publication Year 2008
Sub-type Published abstract
DOI 10.1177/1352458508096399
Open Access Status Not Open Access
ISSN 1352-4585
1477-0970
Volume 14
Issue Supp. 1
Start page S60
End page S60
Total pages 1
Language eng
Formatted Abstract/Summary
Background: A large body of epidemiological evidence indicates that infection with Epstein-Barr virus (EBV) has a role in the pathogenesis of several human autoimmune diseases including multiple sclerosis (MS). Recent studies have shown abnormal immunity to EBV and large numbers of EBV-infected B cells in the brains of MS patients, and have suggested that this contributes to the pathogenesis of the disease. Previous sequence analysis of various EBV antigens has shown significant polymorphism between isolates from healthy donors of different ethnic groups.

Conclusions: These results indicate that a comprehensive investigation into the functional and immunological impact of this EBNA-1 sequence polymorphism is required, along with sequence analysis of other EBV genes from strains infecting MS patients. The identification of specific EBV strain variation associated with MS may open new avenues for fighting this debilitating disease.
Subjects 320207 Autoimmunity
Q-Index Code EX
Q-Index Status Provisional Code
Institutional Status UQ
Additional Notes Publication date: September 2008. Presented during and published under the Poster Session "Epidemiology/Genetics – Part 1" as Poster P105.

Document type: Conference Paper
Collection: School of Medicine Publications
 
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Created: Thu, 03 Feb 2011, 20:24:46 EST by Mr Peter Csurhes on behalf of Medicine - Royal Brisbane and Women's Hospital