NLRP3 inflammasome activation: The convergence of multiple signalling pathways on ROS production?

Tschopp, Jurg and Schroder, Kate (2010) NLRP3 inflammasome activation: The convergence of multiple signalling pathways on ROS production?. Nature Reviews Immunology, 10 3: 210-215. doi:10.1038/nri2725


Author Tschopp, Jurg
Schroder, Kate
Title NLRP3 inflammasome activation: The convergence of multiple signalling pathways on ROS production?
Journal name Nature Reviews Immunology   Check publisher's open access policy
ISSN 1474-1733
Publication date 2010-03-01
Year available 2010
Sub-type Article (original research)
DOI 10.1038/nri2725
Open Access Status Not yet assessed
Volume 10
Issue 3
Start page 210
End page 215
Total pages 6
Place of publication England
Publisher Nature Pub. Group
Language eng
Abstract The NLR family, pyrin domain-containing 3 (NLRP3) inflammasome is a multiprotein complex that activates caspase 1, leading to the processing and secretion of the pro-inflammatory cytokines interleukin-1Β (IL-1Β) and IL-18. The NLRP3 inflammasome is activated by a wide range of danger signals that derive not only from microorganisms but also from metabolic dysregulation. It is unclear how these highly varied stress signals can be detected by a single inflammasome. In this Opinion article, we review the different signalling pathways that have been proposed to engage the NLRP3 inflammasome and suggest a model in which one of the crucial elements for NLRP3 activation is the generation of reactive oxygen species (ROS). © 2010 Macmillan Publishers Limited. All rights reserved.
Keyword Nod-Like Receptors
Nalp3 Inflammasome
P2X(7) Receptor
Caspase-1
Release
Atp
Il-1-Beta
Crystals
Defense
Silica
Q-Index Code C1
Q-Index Status Confirmed Code
Grant ID ID 490993
Institutional Status Non-UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: Non HERDC
Institute for Molecular Bioscience - Publications
 
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Created: Thu, 03 Feb 2011, 03:16:37 EST by Dr Kate Schroder on behalf of Institute for Molecular Bioscience