The inflammasomes

Schroder, Kate and Tschopp, Jurg (2010) The inflammasomes. Cell, 140 6: 821-832. doi:10.1016/j.cell.2010.01.040

Author Schroder, Kate
Tschopp, Jurg
Title The inflammasomes
Journal name Cell   Check publisher's open access policy
ISSN 0092-8674
Publication date 2010-03-01
Year available 2010
Sub-type Critical review of research, literature review, critical commentary
DOI 10.1016/j.cell.2010.01.040
Open Access Status Not yet assessed
Volume 140
Issue 6
Start page 821
End page 832
Total pages 12
Place of publication Cambridge, MA, U.S.A.
Publisher Cell Press
Language eng
Abstract Inflammasomes are molecular platforms activated upon cellular infection or stress that trigger the maturation of proinflammatory cytokines such as interleukin-1β to engage innate immune defenses. Strong associations between dysregulated inflammasome activity and human heritable and acquired inflammatory diseases highlight the importance this pathway in tailoring immune responses. Here, we comprehensively review mechanisms directing normal inflammasome function and its dysregulation in disease. Agonists and activation mechanisms of the NLRP1, NLRP3, IPAF, and AIM2 inflammasomes are discussed. Regulatory mechanisms that potentiate or limit inflammasome activation are examined, as well as emerging links between the inflammasome and pyroptosis and autophagy. © 2010 Elsevier Inc.
Keyword Nf-Kappa-B
Cold Autoinflammatory Syndrome
Anthrax Lethal Toxin
Interleukin-1 Receptor Antagonist
Legionella-Pneumophila Infection
Familial Mediterranean Fever
Innate Immune-Responses
Caspase-1 Activation
Nalp3 Inflammasome
Q-Index Code C1
Q-Index Status Confirmed Code
Grant ID ID 490993
Institutional Status Non-UQ
Additional Notes Available online 18 March, 2010.

Document type: Journal Article
Sub-type: Critical review of research, literature review, critical commentary
Collections: Non HERDC
Institute for Molecular Bioscience - Publications
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Citation counts: TR Web of Science Citation Count  Cited 1992 times in Thomson Reuters Web of Science Article | Citations
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Created: Thu, 03 Feb 2011, 03:08:11 EST by Dr Kate Schroder on behalf of Institute for Molecular Bioscience