Pandemic pharmaceutical dosing effects on wastewater treatment: No adaptation of activated sludge bacteria to degrade the antiviral drug Oseltamivir (Tamiflu®) and loss of nutrient removal performance

Slater, Frances R., Singer, Andrew C., Turner, Susan, Barr, Jeremy J. and Bond, Philip L. (2011) Pandemic pharmaceutical dosing effects on wastewater treatment: No adaptation of activated sludge bacteria to degrade the antiviral drug Oseltamivir (Tamiflu®) and loss of nutrient removal performance. Fems Microbiology Letters, 315 1: 17-22. doi:10.1111/j.1574-6968.2010.02163.x


Author Slater, Frances R.
Singer, Andrew C.
Turner, Susan
Barr, Jeremy J.
Bond, Philip L.
Title Pandemic pharmaceutical dosing effects on wastewater treatment: No adaptation of activated sludge bacteria to degrade the antiviral drug Oseltamivir (Tamiflu®) and loss of nutrient removal performance
Journal name Fems Microbiology Letters   Check publisher's open access policy
ISSN 0378-1097
1574-6968
Publication date 2011-02-01
Year available 2010
Sub-type Article (original research)
DOI 10.1111/j.1574-6968.2010.02163.x
Volume 315
Issue 1
Start page 17
End page 22
Total pages 6
Editor Elizabeth Baggs
Jeff A. Cole
Place of publication Oxford, U.K.
Publisher Blackwell
Language eng
Formatted abstract
he 2009–2010 influenza pandemic saw many people treated with antivirals and antibiotics. High proportions of both classes of drugs are excreted and enter wastewater treatment plants (WWTPs) in biologically active forms. To date, there has been no study into the potential for influenza pandemic-scale pharmaceutical use to disrupt WWTP function. Furthermore, there is currently little indication as to whether WWTP microbial consortia can degrade antiviral neuraminidase inhibitors when exposed to pandemic-scale doses. In this study, we exposed an aerobic granular sludge sequencing batch reactor, operated for enhanced biological phosphorus removal (EBPR), to a simulated influenza-pandemic dosing of antibiotics and antivirals for 8 weeks. We monitored the removal of the active form of Tamiflu®, oseltamivir carboxylate (OC), bacterial community structure, granule structure and changes in EBPR and nitrification performance. There was little removal of OC by sludge and no evidence that the activated sludge community adapted to degrade OC. There was evidence of changes to the bacterial community structure and disruption to EBPR and nitrification during and after high-OC dosing. This work highlights the potential for the antiviral contamination of receiving waters and indicates the risk of destabilizing WWTP microbial consortia as a result of high concentrations of bioactive pharmaceuticals during an influenza pandemic.
© 2010 Federation of European Microbiological Societies
Published by Blackwell Publishing Ltd. All rights reserved

Keyword Antiviral degradation
Pharmaceutical ecotoxicity
Enhanced biological phosphorus removal (EBPR)
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ
Additional Notes Article first published online: 6 DEC 2010

Document type: Journal Article
Sub-type: Article (original research)
Collections: Official 2011 Collection
Advanced Water Management Centre Publications
 
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Created: Thu, 06 Jan 2011, 23:38:12 EST by Hong Lee on behalf of Advanced Water Management Centre