Management of high genetic risk bowel cancer

Leggett, Barbara (2010). Management of high genetic risk bowel cancer. In Monica C. Robotin, Ian N. Olver and Afaf Girgis (Ed.), When Cancer Crosses Disciplines: A Clinician's Handbook (pp. 969-979) London, UK: Imperial College Press.

Attached Files (Some files may be inaccessible until you login with your UQ eSpace credentials)
Name Description MIMEType Size Downloads
WhenCancerCrossesChap40.pdf HERDC Full text - Not publicly available application/pdf 4.85MB 0

Author Leggett, Barbara
Title of chapter Management of high genetic risk bowel cancer
Title of book When Cancer Crosses Disciplines: A Clinician's Handbook
Place of Publication London, UK
Publisher Imperial College Press
Publication Year 2010
Sub-type Other
Editor Monica C. Robotin
Ian N. Olver
Afaf Girgis
Volume number 40
Chapter number 11
Start page 969
End page 979
Total pages 11
Total chapters 48
Collection year 2011
Language eng
Subjects 1111 Nutrition and Dietetics
Formatted Abstract/Summary
The identification and appropriate genetic counselling of individuals at high genetic risk of bowel cancer is an excellent example of how improved understanding of the genetic basis of disease can lead to reduction in morbidity and mortality. The key to good management is to make as accurate a diagnosis of the family syndrome as possible, since different syndromes require different surveillance regimens. Diagnosis requires not only verification of cancer diagnoses in the family, but also consideration of the number and types of polyps detected at colonoscopy and in colectomy specimens. In addition, assays to detect microsatellite instability in cancer specimens aid in the diagnosis of Lynch syndrome. Since so much can be done to prevent cancer developing in at risk individuals, a major challenge in the future is how best to disseminate knowledge within a family and how to encourage compliance with appropriate surveillance.
Keyword Colorectal cancer polyposis
Lynch syndrome
Q-Index Code BX
Q-Index Status Confirmed Code
Institutional Status UQ
Additional Notes This article was first published in Cancer Forum: Clinical Cancer Genetics, Vol. 31, No. 3, November2007 (by Cancer CouncilAustralia). Reproduced with permission from the authors and publishers.

Version Filter Type
Citation counts: Google Scholar Search Google Scholar
Created: Mon, 20 Dec 2010, 15:42:21 EST by Maria Campbell on behalf of Royal Brisbane Clinical School