Measurement of gliclazide in plasma by radial compression reversed-phase liquid chromatography

Charles, Bruce G. and Ravenscroft, Peter J. (1984) Measurement of gliclazide in plasma by radial compression reversed-phase liquid chromatography. Clinical Chemistry, 30 11: 1789-1791.

Author Charles, Bruce G.
Ravenscroft, Peter J.
Title Measurement of gliclazide in plasma by radial compression reversed-phase liquid chromatography
Journal name Clinical Chemistry   Check publisher's open access policy
ISSN 0009-9147
1530-8561
Publication date 1984-11-01
Year available 1984
Sub-type Article (original research)
Volume 30
Issue 11
Start page 1789
End page 1791
Total pages 3
Place of publication Washington, DC, United States
Publisher American Association for Clinical Chemistry
Language eng
Abstract We describe a rapid, specific, and precise analysis for gliclazide in plasma by radial compression, reversed-phase, 'high-performance' liquid chromatography. Gliclazide and the internal standard, 3-chlorogliclazide, are eluted after 4.4 and 6.8 min, respectively. Only 100 μL of plasma and minimal sample workup are required. The limit of detection for gliclazide in plasma is 0.5 mg/L (1.55 μmol/L) at 229 nm. Precision (CV) of the assay for 10 and 1 mg of gliclazide per litre is 2.1% and 6.4%, respectively.
Keyword Medical Laboratory Technology
Medical Laboratory Technology
MEDICAL LABORATORY TECHNOLOGY
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Non-UQ

Document type: Journal Article
Sub-type: Article (original research)
Collection: School of Pharmacy Publications
 
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Created: Mon, 20 Dec 2010, 23:49:31 EST