The role of calcium in intracellular trafficking

Micaroni, M. (2010) The role of calcium in intracellular trafficking. Current Molecular Medicine, 10 8: 763-773. doi:10.2174/156652410793384204

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Author Micaroni, M.
Title The role of calcium in intracellular trafficking
Journal name Current Molecular Medicine   Check publisher's open access policy
ISSN 1566-5240
Publication date 2010-11-01
Sub-type Critical review of research, literature review, critical commentary
DOI 10.2174/156652410793384204
Volume 10
Issue 8
Start page 763
End page 773
Total pages 11
Place of publication Bussum, Netherlands
Publisher Bentham Science Publishers
Language eng
Formatted abstract
The molecular mechanism of membrane fusion essential to vital cellular activities such as intracellular transport, hormone secretion, enzyme release, or neurotransmission, involve the assembly and disassembly of a specialized set of proteins in opposing bilayers. Recent evidences shed new light on the role Ca2+ has in the regulation of this mechanism in which the Golgi apparatus works as a central station; from here, Ca2+ ions are released into and recovered from the cytosol during the different steps of the cargo progression. In fact, transient cytosolic Ca2+ fluctuations take a crucial role to recruit proteins and enzymes Ca2+-sensitive on Golgi membranes where they are involved in membranes remodelling which is fundamental process for the fusion events that allow protein trafficking. Here I provide an overview of the role Ca2+ plays in intra-Golgi trafficking underlying some interesting aspects to clarify the mechanisms of cargo progression. © 2010 Bentham Science Publishers Ltd.
Keyword ATPase calcium pump
Golgi apparatus
Intra-Golgi trafficking
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Critical review of research, literature review, critical commentary
Collections: Official 2011 Collection
Institute for Molecular Bioscience - Publications
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Citation counts: TR Web of Science Citation Count  Cited 11 times in Thomson Reuters Web of Science Article | Citations
Scopus Citation Count Cited 12 times in Scopus Article | Citations
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Created: Sun, 12 Dec 2010, 10:10:03 EST