Association of statin prescription with small abdominal aortic aneurysm progression

Ferguson, Craig D., Clancy, Paula, Bourke, Bernard, Walker, Philip J., Dear, Anthony, Buckenham, Tim, Norman, Paul and Golledge, Jonathan (2010) Association of statin prescription with small abdominal aortic aneurysm progression. American Heart Journal, 159 2: 307-313. doi:10.1016/j.ahj.2009.11.016


Author Ferguson, Craig D.
Clancy, Paula
Bourke, Bernard
Walker, Philip J.
Dear, Anthony
Buckenham, Tim
Norman, Paul
Golledge, Jonathan
Title Association of statin prescription with small abdominal aortic aneurysm progression
Journal name American Heart Journal   Check publisher's open access policy
ISSN 0002-8703
1097-6744
Publication date 2010-02-01
Sub-type Article (original research)
DOI 10.1016/j.ahj.2009.11.016
Open Access Status Not Open Access
Volume 159
Issue 2
Start page 307
End page 313
Total pages 7
Place of publication St. Louis, MO, U.S.A.
Publisher Mosby
Language eng
Abstract It has been suggested that diabetes medications, such as metformin, may have effects that inhibit abdominal aortic aneurysm (AAA) growth. The aim of this study was to examine the association of diabetes treatments with AAA growth in three patient cohorts.
Formatted abstract
Background: Statins have been suggested to reduce expansion of abdominal aortic aneurysms (AAAs) independent of lipid-lowering effects. Methods: We assessed the association of statin treatment and serum low-density lipoprotein (LDL) concentrations with small AAA expansion. Six hundred fifty-two patients undergoing surveillance of small AAAs were entered into the study from 5 vascular centers. In a subset, fasting lipids (n = 451) and other biomarkers (n = 216) were measured. The AAA diameter was followed by ultrasound surveillance for a median of 5 years. Results: Three hundred forty-nine (54%) of the patients were prescribed statins. Adjusting for other risk factors, statin prescription was not associated with AAA growth (odds ratio [OR] 1.23, 95% CI 0.86-1.76). Above-median AAA growth was positively associated with initial diameter (OR 1.78 per 4.35-mm-larger initial aortic diameter, 95% CI 1.49-2.14) and negatively associated with diabetes (OR 0.37, 95% CI 0.22-0.62). Above-median serum LDL concentration was not associated with AAA growth. Patients receiving statins had lower serum C-reactive protein concentrations but similar matrix metalloproteinase-9 and interleukin-6 concentrations to those not prescribed these medications. Conclusions: We found no association between statin prescription or LDL concentration with AAA expansion. The results do not support the findings of smaller studies and suggest that statins may have no benefit in reducing AAA progression.
© 2010 Mosby, Inc. All rights reserved.
Keyword C-Reactive Protein (CRP)
Controlled-trial
Expansion Rate
Risk-factors
Double-blind
Repair
Surveillance
Simvastatin
Outcomes
Plasma
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ
Additional Notes Received 25 July 2009; accepted 18 November 2009. Available online 2 February 2010

Document type: Journal Article
Sub-type: Article (original research)
Collections: UQ Centre for Clinical Research Publications
Official 2011 Collection
School of Medicine Publications
 
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Created: Tue, 07 Dec 2010, 00:35:42 EST by Lisa Hennell on behalf of Surgery - Royal Brisbane and Women's Hospital