Sry: the master switch in mammalian sex determination

Kashimada, K and Koopman, P (2010) Sry: the master switch in mammalian sex determination. Development, 137 23: 3921-3930. doi:10.1242/dev.048983

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Author Kashimada, K
Koopman, P
Title Sry: the master switch in mammalian sex determination
Journal name Development   Check publisher's open access policy
ISSN 0950-1991
Publication date 2010-12-01
Year available 2010
Sub-type Article (original research)
DOI 10.1242/dev.048983
Open Access Status File (Publisher version)
Volume 137
Issue 23
Start page 3921
End page 3930
Total pages 10
Place of publication Cambridge, United Kingdom
Publisher The Company of Biologists
Language eng
Subject 1312 Molecular Biology
1309 Developmental Biology
Abstract SRY, the mammalian Y-chromosomal testis-determining gene, induces male sex determination. Recent studies in mice reveal that the major role of SRY is to achieve sufficient expression of the related gene Sox9, in order to induce Sertoli cell differentiation, which in turn drives testis formation. Here, we discuss the cascade of events triggered by SRY and the mechanisms that reinforce the differentiation of the testes in males while actively inhibiting ovarian development. © Copyright 2010 The Company of Biologists Ltd.
Keyword Sry
Sex determination
Sertoli cell
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: Official 2011 Collection
Institute for Molecular Bioscience - Publications
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Citation counts: TR Web of Science Citation Count  Cited 134 times in Thomson Reuters Web of Science Article | Citations
Scopus Citation Count Cited 148 times in Scopus Article | Citations
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Created: Sun, 05 Dec 2010, 10:14:56 EST