The clinical potential and challenges of sequencing cancer genomes for personalized medical genomics

Cloonan, N., Waddell, N. and Grimmond, S. M. (2010) The clinical potential and challenges of sequencing cancer genomes for personalized medical genomics. I Drugs, 13 11: 778-781.


Author Cloonan, N.
Waddell, N.
Grimmond, S. M.
Title The clinical potential and challenges of sequencing cancer genomes for personalized medical genomics
Journal name I Drugs   Check publisher's open access policy
ISSN 1369-7056
Publication date 2010-11-01
Sub-type Critical review of research, literature review, critical commentary
Volume 13
Issue 11
Start page 778
End page 781
Total pages 4
Place of publication United Kingdom
Publisher Current Drugs
Language eng
Abstract Next-generation sequencing is revolutionizing the way in which genomic-scale biological research is performed, and its effects are beginning to be translated medically. Large-scale international collaborations for the comprehensive sequencing of the genome, epigenome, and transcriptomes of cancers and corresponding 'normal' (germ-line) DNA are heralding the start of personalized medical genomics. The promise of eliminating conjecture when determining treatment approaches is certainly appealing for both patients and clinicians; however, several major issues must be resolved before next-generation sequencing will be adopted as a routine clinical tool for patients. This feature review explores the clinical potential and challenges of studying cancer genomes for personalized medical genomics. © Thomson Reuters (Scientific) Ltd.
Keyword Bioinformatics
Biomarker
Cancer
Ethics
Next-generation Sequencing
Personalized Medical Genomics
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Critical review of research, literature review, critical commentary
Collections: Official 2011 Collection
Institute for Molecular Bioscience - Publications
 
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Created: Sun, 28 Nov 2010, 10:05:42 EST