GS28, a 28-kilodalton golgi SNARE that participates in ER-Golgi transport

Subramaniam, V. N., Peter, F., Philp, R., Wong, S. H. and Hong, W. J. (1996) GS28, a 28-kilodalton golgi SNARE that participates in ER-Golgi transport. Science, 272 5265: 1161-1163. doi:10.1126/science.272.5265.1161


Author Subramaniam, V. N.
Peter, F.
Philp, R.
Wong, S. H.
Hong, W. J.
Title GS28, a 28-kilodalton golgi SNARE that participates in ER-Golgi transport
Journal name Science   Check publisher's open access policy
ISSN 0036-8075
Publication date 1996-05-01
Year available 1996
Sub-type Article (original research)
DOI 10.1126/science.272.5265.1161
Open Access Status Not yet assessed
Volume 272
Issue 5265
Start page 1161
End page 1163
Total pages 3
Place of publication WASHINGTON
Publisher AMER ASSOC ADVANCEMENT SCIENCE
Language eng
Abstract Little is known about the integral membrane proteins that participate in the early secretory pathway of mammalian cells. The complementary DNA encoding a 28-kilodalton protein (p28) of the cis-Golgi was cloned and sequenced. The protein was predicted to contain a central coiled-coil domain with a carboxyl-terminal membrane anchor. An in vitro assay for endoplasmic reticulum-Golgi transport was used to show that p28 participates in the docking and fusion stage of this transport event. Biochemical studies established that p28 is a core component of the Golgi SNAP receptor (SNARE) complex.
Keyword VESICULAR TRANSPORT
ENDOPLASMIC-RETICULUM
FUSION
RECEPTORS
PROTEIN
FAMILY
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Unknown

Document type: Journal Article
Sub-type: Article (original research)
Collection: School of Medicine Publications
 
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