Multiresistant Gram-negative infections: A global perspective

Ho, J, Tambyah, PA and Paterson, DL (2010) Multiresistant Gram-negative infections: A global perspective. Current Opinion in Infectious Diseases, 23 6: 546-553. doi:10.1097/QCO.0b013e32833f0d3e

Author Ho, J
Tambyah, PA
Paterson, DL
Title Multiresistant Gram-negative infections: A global perspective
Journal name Current Opinion in Infectious Diseases   Check publisher's open access policy
ISSN 0951-7375
Publication date 2010-12-01
Sub-type Critical review of research, literature review, critical commentary
DOI 10.1097/QCO.0b013e32833f0d3e
Volume 23
Issue 6
Start page 546
End page 553
Total pages 8
Place of publication Philadelphia, PA, United States
Publisher Lippincott Williams & Wilkins
Language eng
Formatted abstract
Purpose of review: Multiresistant Gram-negative infections are an increasing problem in hospitals and healthcare facilities worldwide. While much attention has been paid to Gram-positive pathogens such as methicillin-resistant Staphylococcus aureus and vancomycin-resistant Enterococcus lately, the importance of Gram-negative nosocomial infections has also been recognized globally.

Recent findings:
Recent reports have described the spread of carbapenemase-producing Klebsiella pneumoniae across North America. In addition, many strains of Pseudomonas and Acinetobacter in Asia are resistant to all known antibiotics. The global epidemiology of multiresistant Gram-negative pathogens seems to vary by continent. There are very few existing agents which can be used for these pathogens and there are limited options on the horizon. This limited therapeutic armamentarium has been an impetus for novel approaches including combination therapies and increased attention to infection control and prevention efforts.

Summary: Clinicians need to be aware of the rising problem of resistance in nosocomial and community-acquired Gram-negative pathogens. Novel agents are urgently needed to combat these infections and innovative infection control strategies need to be devised to protect our vulnerable patients.
Copyright: © 2010 Lippincott Williams & Wilkins, Inc.
Keyword Antibiotic resistance
Gram-negative infection
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Critical review of research, literature review, critical commentary
Collections: UQ Centre for Clinical Research Publications
Official 2011 Collection
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Citation counts: TR Web of Science Citation Count  Cited 88 times in Thomson Reuters Web of Science Article | Citations
Scopus Citation Count Cited 92 times in Scopus Article | Citations
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Created: Sun, 21 Nov 2010, 10:06:14 EST