Suppression of neutrophil and lymphoproliferative responses in vitro by itraconazole but not fluconazole

Vuddhakul, V., Mai, G. T., McCormack, J. G., Seow, W. K. and Thong, Y. H. (1990) Suppression of neutrophil and lymphoproliferative responses in vitro by itraconazole but not fluconazole. International Journal of Immunopharmacology, 12 6: 639-645. doi:10.1016/0192-0561(90)90101-R


Author Vuddhakul, V.
Mai, G. T.
McCormack, J. G.
Seow, W. K.
Thong, Y. H.
Title Suppression of neutrophil and lymphoproliferative responses in vitro by itraconazole but not fluconazole
Journal name International Journal of Immunopharmacology   Check publisher's open access policy
ISSN 0192-0561
Publication date 1990-01-01
Year available 1990
Sub-type Article (original research)
DOI 10.1016/0192-0561(90)90101-R
Open Access Status Not yet assessed
Volume 12
Issue 6
Start page 639
End page 645
Total pages 7
Place of publication OXFORD
Publisher PERGAMON-ELSEVIER SCIENCE LTD
Language eng
Subject 2403 Immunology
3004 Pharmacology
Abstract Itraconazole and fluconazole are triazole compounds recently licensed for the therapy of systemic fungal infections. At 10 μg/ml concentrations, itraconazole was found to suppress neutrophil chemotaxis, random movement, deoxyglucose uptake and hexose-monophosphate shunt activity to the same extent as ketoconazole, an older generation azole antifungal. Itraconazole was also found to suppress mitogen-induced lymphocyte transformation to the same extent as ketoconazole at concentrations as low as 1 μg/ml. By contrast, significant inhibition of both neutrophil and lymphocyte functions was not observed with fluconazole at concentrations as high as 50 μg/ml. These results suggest that fluconazole may be less immunotoxic than itraconazole, and may be more suitable for use in immunocompromised patients.
Keyword Immunology
Pharmacology & Pharmacy
Immunology
Pharmacology & Pharmacy
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Unknown

Document type: Journal Article
Sub-type: Article (original research)
Collection: School of Dentistry Publications
 
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Created: Thu, 18 Nov 2010, 21:05:11 EST