Sensitivity in vitro of Giardia intestinalis to dyadic combinations of azithromycin, doxycycline, mefloquine, tinidazole and furazolidone

Crouch, A. A., Seow, W. K., Whitman, L. M. and Thong, Y. H. (1990) Sensitivity in vitro of Giardia intestinalis to dyadic combinations of azithromycin, doxycycline, mefloquine, tinidazole and furazolidone. Transactions of the Royal Society of Tropical Medicine and Hygiene, 84 2: 246-248. doi:10.1016/0035-9203(90)90273-H


Author Crouch, A. A.
Seow, W. K.
Whitman, L. M.
Thong, Y. H.
Title Sensitivity in vitro of Giardia intestinalis to dyadic combinations of azithromycin, doxycycline, mefloquine, tinidazole and furazolidone
Journal name Transactions of the Royal Society of Tropical Medicine and Hygiene   Check publisher's open access policy
ISSN 0035-9203
Publication date 1990-03-01
Year available 1990
Sub-type Article (original research)
DOI 10.1016/0035-9203(90)90273-H
Open Access Status Not yet assessed
Volume 84
Issue 2
Start page 246
End page 248
Total pages 3
Place of publication LONDON
Publisher ROYAL SOC TROPICAL MEDICINE
Language eng
Subject 2405 Parasitology
2739 Public Health, Environmental and Occupational Health
2725 Infectious Diseases
Abstract The new macrolide antibiotic, azithromycin, produced significant growth inhibition of Giardia intestinalis at 100 μg/ml, but adherence inhibition was significant at concentrations as low as 1 μg/ml for the two strains used in these experiments. The dyadic combinations of azithromycin-furazolidone, doxycycline-mefloquine, doxycycline-tinidazole and mefloquine-tinidazole were synergistic for inhibition of adherence. These results suggest that these dyadic combinations may be worthy of consideration for chemotherapy of recalcitrant giardiasis.
Keyword Public, Environmental & Occupational Health
Tropical Medicine
Public, Environmental & Occupational Health
Tropical Medicine
PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH, SCI
TROPICAL MEDICINE
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collection: School of Dentistry Publications
 
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Created: Thu, 18 Nov 2010, 21:00:19 EST