Inhibition of adherence of Giardia intestinalis by human neutrophils and monocytes

Crouch, A. A., Seow, W. K., Whitman, L. M., Smith, S. E. and Thong, Y. H. (1991) Inhibition of adherence of Giardia intestinalis by human neutrophils and monocytes. Transactions of the Royal Society of Tropical Medicine and Hygiene, 85 3: 375-379. doi:10.1016/0035-9203(91)90297-C


Author Crouch, A. A.
Seow, W. K.
Whitman, L. M.
Smith, S. E.
Thong, Y. H.
Title Inhibition of adherence of Giardia intestinalis by human neutrophils and monocytes
Journal name Transactions of the Royal Society of Tropical Medicine and Hygiene   Check publisher's open access policy
ISSN 0035-9203
Publication date 1991-05-01
Year available 1991
Sub-type Article (original research)
DOI 10.1016/0035-9203(91)90297-C
Open Access Status Not yet assessed
Volume 85
Issue 3
Start page 375
End page 379
Total pages 5
Place of publication LONDON
Publisher ROYAL SOC TROPICAL MEDICINE
Language eng
Abstract Human neutrophils and monocytes were found to be capable of interfering with the in vitro adherence of Giardia intestinalis. Significantly greater inhibition of adherence was shown by stimulated phagocytic cells than by unstimulated cells. Both azurophil and specific granules extracted from the cytoplasm of neutrophils were equally potent in their adherence inhibitory activity. Dose-dependent effects on adherence were observed with granular enzymes and reactive oxygen species. Lower concentrations of reactive oxygen species were required for adherence inhibition that for growth inhibition. These results suggest that the adherence mechanism of G. intestinalis may be a feasible target for immunological attack by phagocytic cells.
Keyword HUMAN HOST RESPONSE
LAMBLIA TROPHOZOITES
ANTIBODY-RESPONSE
CANDIDA-ALBICANS
MURIS
INVITRO
ATTACHMENT
INFECTION
MECHANISM
ACTIVATION
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Unknown

Document type: Journal Article
Sub-type: Article (original research)
Collection: School of Dentistry Publications
 
Versions
Version Filter Type
Citation counts: TR Web of Science Citation Count  Cited 15 times in Thomson Reuters Web of Science Article | Citations
Scopus Citation Count Cited 13 times in Scopus Article | Citations
Google Scholar Search Google Scholar
Created: Thu, 18 Nov 2010, 21:00:14 EST