The Essential Role of Epstein-Barr Virus in the Pathogenesis of Multiple Sclerosis

Pender, Michael P. (2011) The Essential Role of Epstein-Barr Virus in the Pathogenesis of Multiple Sclerosis. Neuroscientist, 17 4: 351-367. doi:10.1177/1073858410381531


Author Pender, Michael P.
Title The Essential Role of Epstein-Barr Virus in the Pathogenesis of Multiple Sclerosis
Journal name Neuroscientist   Check publisher's open access policy
ISSN 1073-8584
Publication date 2011-08-01
Year available 2010
Sub-type Article (original research)
DOI 10.1177/1073858410381531
Open Access Status Not yet assessed
Volume 17
Issue 4
Start page 351
End page 367
Total pages 17
Language eng
Subject 110904 Neurology and Neuromuscular Diseases
110703 Autoimmunity
Abstract There is increasing evidence that infection with the Epstein-Barr virus (EBV) plays a role in the development of multiple sclerosis (MS), a chronic inflammatory demyelinating disease of the CNS. This article provides a four-tier hypothesis proposing (1) EBV infection is essential for the development of MS; (2) EBV causes MS in genetically susceptible individuals by infecting autoreactive B cells, which seed the CNS where they produce pathogenic autoantibodies and provide costimulatory survival signals to autoreactive T cells that would otherwise die in the CNS by apoptosis; (3) the susceptibility to develop MS after EBV infection is dependent on a genetically determined quantitative deficiency of the cytotoxic CD8+ T cells that normally keep EBV infection under tight control; and (4) sunlight and vitamin D protect against MS by increasing the number of CD8+ T cells available to control EBV infection. The hypothesis makes predictions that can be tested, including the prevention and successful treatment of MS by controlling EBV infection.
Keyword multiple sclerosis
Epstein-Barr virus
Cd8 T Cell
vitamin D
Sunlight
Treatment
Autoimmune
vaccination
ultraviolet radiation
rituximab
prevention
latitude
Immunity
EBV
B cell
autoreactive
Antibody
antiviral drug
Autoimmune Disease
autoimmune thyroid disease
autoimmunity
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ
Additional Notes Published online before print November 12, 2010,

Document type: Journal Article
Sub-type: Article (original research)
Collections: Official 2011 Collection
School of Medicine Publications
 
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Citation counts: TR Web of Science Citation Count  Cited 54 times in Thomson Reuters Web of Science Article | Citations
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Created: Thu, 18 Nov 2010, 19:58:11 EST by Mr Lawson Peters on behalf of Social Sciences and Humanities Library Service