Partitioning of alterations in pulmonary mechanics due to vascular engorgement in piglets

Wildhaber, J.H., Uhlig, T. and Sly, P.D. (1998) Partitioning of alterations in pulmonary mechanics due to vascular engorgement in piglets. Pediatric Pulmonology, 25 1: 45-51. doi:10.1002/(SICI)1099-0496(199801)25:1<45::AID-PPUL5>3.0.CO;2-N

Author Wildhaber, J.H.
Uhlig, T.
Sly, P.D.
Title Partitioning of alterations in pulmonary mechanics due to vascular engorgement in piglets
Journal name Pediatric Pulmonology   Check publisher's open access policy
ISSN 8755-6863
Publication date 1998-01-01
Sub-type Article (original research)
DOI 10.1002/(SICI)1099-0496(199801)25:1<45::AID-PPUL5>3.0.CO;2-N
Volume 25
Issue 1
Start page 45
End page 51
Total pages 7
Place of publication Hoboken, NJ, United States
Publisher John Wiley & Sons
Language eng
Abstract The aim of our study was to determine the effects of pulmonary vascular engorgement on airways and pulmonary tissues in juvenile animals before and after methacholine (Mch)-induced changes in lung function. Five anesthetized, paralyzed, and thoracotomized piglets were studied before and during pulmonary vascular engorgement, induced by inflating a left atrial balloon catheter and by calculating respiratory mechanics from measurements of airway opening (P(ao)) and alveolar pressures (P(A)), respiretory flow (V'), and volume (V) recorded during mechanical ventilation, using the multilinear regression technique. A maximal increase of 15 mmHg in pulmonary artery pressure (P(pa)) resulted in a mean increase in total lung elastance (E(L)) of 28.6% and in total lung resistance (R(L) of 14.9%. Mch increased E(L) by 21.7% and R(L) by 29.0%. Inflation of the left atrial balloon with an associated increase in P(pa) by 15 mmHg in the presence of Mch resulted in an increase in E(L) by a further 12.4% (to 135.4% of baseline) and in R(L) by a further 9.0% (to 139.5% of baseline). The change in R(L) was associated with a qualitatively similar change in both tissue resistance (V(ti)) and airway resistance (R(aw)) before and after Mch-induced changes in lung function. We conclude that increasing pulmonary vascular pressures, by increasing left artial pressure, alters lung function in juvenile animals by altering the mechanical properties of both airways and lung tissues. The methods used in the present study allow a direct assessment of the site of action of vascular engorgement in the lungs and provide a useful model for studying this phenomenon further.
Keyword Vascular engorgement
Lung function
Pulmonary mechanics
Airway resistance
Tissue resistance
Animal studies
Methacholine challenge
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Non-UQ

Document type: Journal Article
Sub-type: Article (original research)
Collection: School of Medicine Publications
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Citation counts: TR Web of Science Citation Count  Cited 4 times in Thomson Reuters Web of Science Article | Citations
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Created: Wed, 17 Nov 2010, 21:58:17 EST