Partitioning of pulmonary responses to inhaled methacholine in puppies

Sly, P. D. and Lanteri, C. J. (1991) Partitioning of pulmonary responses to inhaled methacholine in puppies. Journal of Applied Physiology, 71 3: 886-891.

Author Sly, P. D.
Lanteri, C. J.
Title Partitioning of pulmonary responses to inhaled methacholine in puppies
Journal name Journal of Applied Physiology   Check publisher's open access policy
ISSN 8750-7587
Publication date 1991-09-01
Year available 1991
Sub-type Article (original research)
Open Access Status Not Open Access
Volume 71
Issue 3
Start page 886
End page 891
Total pages 6
Place of publication Bethesda, MD, United States
Publisher American Physiological Society
Language eng
Abstract Twelve open-chest mongrel puppies, 8-10 wk old, were studied to localize the site of action of inhaled methacholine within the lungs. Six puppies were challenged with methacholine aerosols and six were challenged with an equal number of nebulizations of normal saline (control group). Pulmonary mechanics were measured during mechanical ventilation and after midexpiratory flow interruptions. Alveolar pressure was measured to allow the partitioning of pulmonary mechanics into airway and tissue components. Good matching between airway opening and alveolar pressures was seen throughout the study. After methacholine challenge, lung resistance increased fivefold. Increases in airway resistance and in the parameters reflecting tissue viscoelastic properties contributed to this increase in lung resistance. Dynamic lung elastance also increased threefold. The response of the methacholine group was statistically different from that of the control group. These data indicate that both the airways and pulmonary parenchyma contribute to the response to inhaled methacholine in 8- to 10-wk-old puppies.
Keyword Airway resistance
Alveolar pressure
Bronchial responsiveness
Viscoelastic properties
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Non-UQ

Document type: Journal Article
Sub-type: Article (original research)
Collection: Faculty of Health and Behavioural Sciences -- Publications
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Created: Wed, 17 Nov 2010, 21:50:42 EST