Do early-life viral infections cause asthma?

Sly, Peter D., Kusel, Merci and Holt, Patrick G. (2010) Do early-life viral infections cause asthma?. Journal of Allergy and Clinical Immunology, 125 6: 1202-1205. doi:10.1016/j.jaci.2010.01.024

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Author Sly, Peter D.
Kusel, Merci
Holt, Patrick G.
Title Do early-life viral infections cause asthma?
Journal name Journal of Allergy and Clinical Immunology   Check publisher's open access policy
ISSN 0091-6749
Publication date 2010-06-01
Sub-type Article (original research)
DOI 10.1016/j.jaci.2010.01.024
Open Access Status Not Open Access
Volume 125
Issue 6
Start page 1202
End page 1205
Total pages 4
Place of publication Philadelphia, PA, U.S.A.
Publisher Mosby, Inc.
Language eng
Formatted abstract
Epidemiologic associations between viral lower respiratory infections (LRIs) and asthma in later childhood are well known. However, the question of whether such infections cause asthma or unmask asthma in a susceptible host has still not been settled. Most early evidence centered on the role of the respiratory syncytial virus; however, recent studies highlight a potential role for human rhinovirus as a risk factor for asthma. The links between early-life viral LRI and subsequent asthma are generally via wheeze; however, the presence of wheeze does not give any information about why the child is wheezing. Wheeze in early life is, at best, a fuzzy phenotype and not specific for subsequent asthma. The risk of asthma after viral LRI is increased in the presence of allergic sensitization in early life and if the infection is more severe. Atopy-associated mechanisms also appear to be involved in viral-induced acute exacerbations of asthma, especially in prolonging symptomatology after the virus has been cleared from the lungs. Breaking the nexus between viral respiratory infections and asthma may be possible with interventions designed to inhibit atopy-related effectors mechanisms from participating in the host response to respiratory viral infections.

Copyright © 2011 Elsevier B.V.
Keyword Allergic sensitization
Human rhinovirus
Respiratory syncytial virus
T cells
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: Official 2011 Collection
School of Medicine Publications
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Citation counts: TR Web of Science Citation Count  Cited 84 times in Thomson Reuters Web of Science Article | Citations
Scopus Citation Count Cited 87 times in Scopus Article | Citations
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Created: Wed, 17 Nov 2010, 21:50:19 EST