Early identification of atopy in the prediction of persistent asthma in children

Sly, Peter D., Boner, Attilio L., Bjorksten, Bngt, Bush, Andy, Custovic, Adnan, Eigenmann, Phillipe A., Gern, James E., Gerritsen, Jorrit, Hamelmann, Eckard, Helms, Peter J., Lemanske, Robert F., Martinez, Fernando, Pedersen, Soren, Renz, Harald, Sampson, Hugh, von Mutius, Erika, Wahn, Ulrich and Holt, Patrick G. (2008) Early identification of atopy in the prediction of persistent asthma in children. The Lancet, 372 9643: 1100-1106. doi:10.1016/S0140-6736(08)61451-8


Author Sly, Peter D.
Boner, Attilio L.
Bjorksten, Bngt
Bush, Andy
Custovic, Adnan
Eigenmann, Phillipe A.
Gern, James E.
Gerritsen, Jorrit
Hamelmann, Eckard
Helms, Peter J.
Lemanske, Robert F.
Martinez, Fernando
Pedersen, Soren
Renz, Harald
Sampson, Hugh
von Mutius, Erika
Wahn, Ulrich
Holt, Patrick G.
Title Early identification of atopy in the prediction of persistent asthma in children
Journal name The Lancet   Check publisher's open access policy
ISSN 0140-6736
1474-547X
0099-5355
Publication date 2008-09-01
Sub-type Critical review of research, literature review, critical commentary
DOI 10.1016/S0140-6736(08)61451-8
Volume 372
Issue 9643
Start page 1100
End page 1106
Total pages 7
Place of publication London, United Kingdom
Publisher The Lancet Publishing Group
Language eng
Abstract The long-term solution to the asthma epidemic is thought to be prevention, and not treatment of established disease. Atopic asthma arises from gene-environment interactions, which mainly take place during a short period in prenatal and postnatal development. These interactions are not completely understood, and hence primary prevention remains an elusive goal. We argue that primary-care physicians, paediatricians, and specialists lack knowledge of the role of atopy in early life in the development of persistent asthma in children. In this review, we discuss how early identification of children at high risk is feasible on the basis of available technology and important for potential benefits to the children. Identification of an asthmatic child's atopic status in early life has practical clinical and prognostic implications, and sets the basis for future preventative strategies.
Keyword Respiratory Syncytial Virus
Childhood Asthma
Birth Cohort
Early-life
Postnatal Maturation
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Non-UQ

Document type: Journal Article
Sub-type: Critical review of research, literature review, critical commentary
Collection: Faculty of Health and Behavioural Sciences -- Publications
 
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Created: Wed, 17 Nov 2010, 21:48:05 EST