Inflammatory profile in nasal secretions of infants hospitalized with acute lower airway tract infections

Pitrez, Paulo M. C., Brennan, Siobhain and Sly, Peter D. (2005) Inflammatory profile in nasal secretions of infants hospitalized with acute lower airway tract infections. Respirology, 10 3: 365-370. doi:10.1111/j.1440-1843.2005.00721.x


Author Pitrez, Paulo M. C.
Brennan, Siobhain
Sly, Peter D.
Title Inflammatory profile in nasal secretions of infants hospitalized with acute lower airway tract infections
Journal name Respirology   Check publisher's open access policy
ISSN 1323-7799
1440-1843
Publication date 2005-06-01
Year available 2005
Sub-type Article (original research)
DOI 10.1111/j.1440-1843.2005.00721.x
Open Access Status Not Open Access
Volume 10
Issue 3
Start page 365
End page 370
Total pages 6
Place of publication Richmond, VIC, Australia
Publisher Wiley-Blackwell
Language eng
Abstract Objective: The aim of this study was to determine whether the regulatory immune response (interleukin (IL)-10 response) differed between children hospitalized with acute respiratory infections and wheezing. Methodology: Infants with signs and symptoms of acute viral respiratory infection, admitted during winter 2000 to Princess Margaret Hospital for Children, Perth, WA, Australia, were enrolled in this study. Nasopharyngeal aspirates were collected in the first 48 h of admission. Total cell count and differential cell counts were assessed. Samples were tested for the presence of respiratory viruses. The concentrations of the anti-inflammatory cytokine IL-10, and pro-inflammatory cytokines IL-8, interferon-γ, and IL-11 were determined by ELISA. Results: Children with acute bronchiolitis (AB; n = 36), recurrent wheeze (RW; n= 17) and upper respiratory infection (URI; n = 18) were enrolled. Respitory syncytial virus was the most commonly detected virus in all groups. IL-10 concentrations were significantly increased in AB (median, 0.019 ng/mL) when compared to URI (median, 0.006 ng/mL) or to RW (median, 0.007 ng/mL; P < 0.05). Neutrophils were the predominant cells in the cytological analysis in all subjects. Conclusion: These data argue that host-response factors are important in determining the clinical phenotype, independent of the causative virus.
Keyword Brazil
cytokines
eosinophils
inflammation
interleukin-10
neutrophils
respiratory syncytial virus
wheezing
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Non-UQ

Document type: Journal Article
Sub-type: Article (original research)
Collection: Faculty of Health and Behavioural Sciences -- Publications
 
Versions
Version Filter Type
Citation counts: TR Web of Science Citation Count  Cited 13 times in Thomson Reuters Web of Science Article | Citations
Scopus Citation Count Cited 15 times in Scopus Article | Citations
Google Scholar Search Google Scholar
Created: Wed, 17 Nov 2010, 21:43:28 EST