Interpretation of interrupter resistance after histamine-induced constriction in the dog

Ludwig, M.S., Romero, P.V., Sly, P.D., Fredberg, J.J. and Bates, J.H.T. (1990) Interpretation of interrupter resistance after histamine-induced constriction in the dog. Journal of Applied Physiology, 68 4: 1651-1656.

Author Ludwig, M.S.
Romero, P.V.
Sly, P.D.
Fredberg, J.J.
Bates, J.H.T.
Title Interpretation of interrupter resistance after histamine-induced constriction in the dog
Journal name Journal of Applied Physiology   Check publisher's open access policy
ISSN 8750-7587
Publication date 1990-04-01
Year available 1990
Sub-type Article (original research)
Open Access Status Not yet assessed
Volume 68
Issue 4
Start page 1651
End page 1656
Total pages 6
Place of publication Bethesda, MD, United States
Publisher American Physiological Society
Language eng
Abstract The interrupter method for measuring respiratory system resistance involves interrupting flow at the airway opening and measuring the resultant changes in pressure. We have recently shown (J. Appl. Physiol. 65: 408-414, 1988) that in open-chest mongrel dogs, under control conditions, the initial rapid pressure change (ΔPinit) reflects conducting airway resistance and the subsequent gradual pressure change (ΔPdif) reflects stress recovery of the tissues. We questioned whether the same interpretation would apply after induced constriction. Accordingly, we performed interruption experiments on anesthetized, paralyzed, tracheostomized, open-chest mongrel dogs during passive expiration, measuring pressure at the trachea and in three different alveolar regions with alveolar capsules. We recorded measurements before and after the administration of increasing concentrations of histamine aerosol (0.1-30.0 mg/ml). We found a significant increase in the heterogeneity of alveolar pressures during the relaxed expiration with increasing concentrations of histamine. Despite the introduction of significant mechanical heterogeneities, ΔPinit still reflected the pressure drop as the result of the resistance of the conducting airways. ΔPdif, however, reflected a combination of the stress recovery of the tissues and pendelluft.
Keyword Alveolar pressure
Heterogeneity of responsiveness
Lung models
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Non-UQ

Document type: Journal Article
Sub-type: Article (original research)
Collection: School of Medicine Publications
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Created: Wed, 17 Nov 2010, 21:37:41 EST