Functional assessment of CD2, CD3 and CD28 on the surface of peripheral blood T-cells from infants at low versus high genetic risk for atopy

Holt, P.G., Somerville, C., Baron-Hay, M.J., Holt, B.J. and Sly, P.D. (1995) Functional assessment of CD2, CD3 and CD28 on the surface of peripheral blood T-cells from infants at low versus high genetic risk for atopy. Pediatric Allergy and Immunology, 6 2: 80-84. doi:10.1111/j.1399-3038.1995.tb00263.x


Author Holt, P.G.
Somerville, C.
Baron-Hay, M.J.
Holt, B.J.
Sly, P.D.
Title Functional assessment of CD2, CD3 and CD28 on the surface of peripheral blood T-cells from infants at low versus high genetic risk for atopy
Journal name Pediatric Allergy and Immunology   Check publisher's open access policy
ISSN 0905-6157
1399-3038
Publication date 1995-05-01
Sub-type Article (original research)
DOI 10.1111/j.1399-3038.1995.tb00263.x
Open Access Status Not Open Access
Volume 6
Issue 2
Start page 80
End page 84
Total pages 5
Place of publication Oxford, United Kingdom
Publisher Wiley-Blackwell
Language eng
Abstract Recent studies from several laboratories suggest that the rate of postnatal maturation of T-cell function(s) associated with in vitro activation may be slower in children at high genetic risk for atopy (HR), compared to their normal (low risk; LR) counterparts. The present study compared the in vitro activity of the function-associated surface molecules CD2, CD3 and CD28 in panels of 27 HR and 13 LR infants, with a reference panel of 10 adults, employing assay systems involving T-cell stimulation with MoAbs against these molecules. The response maxima induced by saturating levels of the MoAbs were equivalent in all 3 groups, but T-cells from the HR infants required 10-50 fold higher levels of anti-CDS stimulation to attain their maximum response, relative to adults (p=0.02); T-cells from LR infants were also less responsive to anti-CD3 than adults, but these differences were smaller and did not attain statistical significance. It is suggested that these differences are attributable to varying proportions of competent T-memory cells (which respond to low levels of anti-CD3) in PBL from these populations, the postnatal accumulation of which proceeds slowest in the HR group.
Keyword Infants
Cord blood
T-Cell subsets
CD2
CD3
CD28
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Non-UQ

Document type: Journal Article
Sub-type: Article (original research)
Collection: School of Medicine Publications
 
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