Altered respiratory tissue mechanics in asymptomatic wheezy infants

Hall, G.L., Hantos, Z. and Sly, P.D (2001) Altered respiratory tissue mechanics in asymptomatic wheezy infants. American Journal of Respiratory and Critical Care Medicine, 164 8: 1387-1391.

Author Hall, G.L.
Hantos, Z.
Sly, P.D
Title Altered respiratory tissue mechanics in asymptomatic wheezy infants
Journal name American Journal of Respiratory and Critical Care Medicine   Check publisher's open access policy
ISSN 1073-449X
Publication date 2001-10-01
Year available 2001
Sub-type Article (original research)
Open Access Status Not Open Access
Volume 164
Issue 8
Start page 1387
End page 1391
Total pages 5
Place of publication New York, NY, United States
Publisher American Thoracic Society
Language eng
Formatted abstract
Low-frequency forced oscillation (LFOT) and raised volume rapid thoracic compression (RVRTC) techniques were used to measure airways and respiratory tissue mechanics and forced expiratory volumes in 24 asymptomatic infants with recurrent wheeze. Total respiratory impedance spectra (Zrs) (0.5 to 20 Hz) were obtained (n = 22) and a model containing airway (resistance [Raw] and inertance [law]) and constant-phase tissue (tissue damping [G] and tissue elastance [H]) compartments fitted to Zrs. Forced expiratory volumes (FEV0.5)were determined (n = 16). Standardized variants (Z scores) were calculated for comparison to a healthy population (Hall et al., Am J Respir Crit Care Med 2000;162:1397-1402). Wheezy infants had elevated H (Z scores: 0.61 ± 0.20; p = 0.007) but not Raw (0.14 ± 0.25; p > 0.2), G (0.41 ± 0.21; p = 0.066), or FEV0.5 (-0.25 ± 0.25; p > 0.2) compared with healthy infants. Infants younger than 1 yr of age were not significantly different from normals, whereas lung function from infants older than 1 yr had deviated from normal infants, with Z scores of 0.58 ± 0.2 (p = 0.018), 0.79 ± 0.31 (p = 0.032), 1.06 ± 0.25 (p = 0.002), and -0.94 ± 0.22 (p = 0.007) for Raw, G, H, and FEV0.5 respectively. We conclude that asymptomatic infants with recurrent wheeze have altered lung function. The abnormalities were more pronounced in respiratory tissue mechanics than in airway mechanics or forced volumes, highlighting the value of techniques capable of partitioning lung function into airway and respiratory tissue components.
Keyword Airway and respiratory tissue mechanics
Wheezy infants
Low-frequency forced oscillations
Forced expiratory volumes
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Non-UQ

Document type: Journal Article
Sub-type: Article (original research)
Collection: School of Medicine Publications
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Citation counts: TR Web of Science Citation Count  Cited 19 times in Thomson Reuters Web of Science Article | Citations
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Created: Wed, 17 Nov 2010, 21:28:56 EST