Effect of pulmonary blood flow on measurements of respiratory mechanics using the interrupter technique

Freezer, N.J., Lanteri, C.J. and Sly, P.D. (1993) Effect of pulmonary blood flow on measurements of respiratory mechanics using the interrupter technique. Journal of Applied Physiology, 74 3: 1083-1088.

Author Freezer, N.J.
Lanteri, C.J.
Sly, P.D.
Title Effect of pulmonary blood flow on measurements of respiratory mechanics using the interrupter technique
Journal name Journal of Applied Physiology   Check publisher's open access policy
ISSN 8750-7587
1522-1601
Publication date 1993-03-01
Year available 1993
Sub-type Article (original research)
Open Access Status Not yet assessed
Volume 74
Issue 3
Start page 1083
End page 1088
Total pages 6
Place of publication Bethesda, MD, United States
Publisher American Physiological Society
Language eng
Abstract The relationship between respiratory mechanics, changes in pulmonary blood flow (PBF), pulmonary arterial pressure, and left atrial pressure is unclear. Conventional methods for the measurement of respiratory mechanics model the respiratory system as a single compartment, which may not adequately represent the respiratory system in a diseased state. The interrupter technique models the respiratory system as two compartments, with the 'flow resistance' of the conducting airways and chest wall (Raw) considered separately from Pdif, a measure of the viscoelastic properties of the lung and chest wall, together with any pendelluft present. The respiratory mechanics of 15 infants in the first year of life were studied during cardiac catheterization with the use of conventional methods and the interrupter technique. The infants had a PBF-to-systemic blood flow ratio ranging from 0.6 to 4.0:1. The specific dynamic compliance of the respiratory system was not related to the PBF; however, there was a significant relationship between PBF and the total resistance of the respiratory system (Rrs) [analysis of variance (ANOVA) F = 5.69, P < 0.05], Raw (ANOVA F = 12.30, P < 0.01), and Pdif (ANOVA, F = 3.79, P < 0.05). Rrs increased significantly with an increase in mean left atrial pressure (ANOVA F = 6.92, P < 0.05); however, dynamic compliance, Raw, and Pdif did not. These results suggest that the relationship between Rrs and PBF is due an increase in the resistive properties of the conducting airways and tissue components.
Keyword Dynamic compliance
Viscoelasticity
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Non-UQ

Document type: Journal Article
Sub-type: Article (original research)
Collection: School of Medicine Publications
 
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Created: Wed, 17 Nov 2010, 21:25:48 EST