The effect of sustained positive airway pressure on derived cardiac output in children

Clough, J.B., Duncan, A.W. and Sly, P.D. (1994) The effect of sustained positive airway pressure on derived cardiac output in children. Anaesthesia and Intensive Care, 22 1: 30-34.

Author Clough, J.B.
Duncan, A.W.
Sly, P.D.
Title The effect of sustained positive airway pressure on derived cardiac output in children
Journal name Anaesthesia and Intensive Care   Check publisher's open access policy
ISSN 0310-057X
Publication date 1994-02-01
Year available 1994
Sub-type Article (original research)
Open Access Status Not Open Access
Volume 22
Issue 1
Start page 30
End page 34
Total pages 5
Place of publication Edgecliff, NSW, Australia
Publisher Australian Society of Anaesthetists
Language eng
Abstract It is well established that the improvement in gas exchange that occurs with positive pressure ventilation may come at the expense of a decrease in cardiac output and oxygen delivery. Clinical observation suggests that children and infants may be more resistant than adults to the falls in cardiac output induced by positive airway pressure. The aims of this study were to quantify the effect of a sustained increase in intrathoracic pressure on cardiac output and stroke volume, and to determine whether this change is age-related. Twenty-eight children undergoing general anaesthesia were studied. Cardiac output was derived using pulsed wave Doppler techniques at four different levels of sustained positive airway pressure, and stroke volume was calculated. The relationship between airway pressure and both cardiac output and stroke volume was examined using a general linear model which included age as a continuous variable. Cardiac output decreased with increasing levels of sustained positive airway pressure (P = 0.001). The fall in SV for a given airway pressure increased with increasing age (P = 0.02). The mechanisms responsible for the increase of the magnitude of the fall in stroke volume with age remain to be elucidated.
Keyword Heart, cardiac output
Positive airway pressure
Ventilation, positive airway pressure
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Non-UQ

Document type: Journal Article
Sub-type: Article (original research)
Collection: School of Medicine Publications
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