The effect of a proximal compliance on interrupter measurements of resistance

Bates, J.H.T., Sly, P.D., Kochi, T. and Martin, J.G. (1987) The effect of a proximal compliance on interrupter measurements of resistance. Respiration Physiology, 70 3: 301-312. doi:10.1016/0034-5687(87)90012-0

Author Bates, J.H.T.
Sly, P.D.
Kochi, T.
Martin, J.G.
Title The effect of a proximal compliance on interrupter measurements of resistance
Journal name Respiration Physiology   Check publisher's open access policy
ISSN 0034-5687
Publication date 1987-12-01
Year available 1987
Sub-type Article (original research)
DOI 10.1016/0034-5687(87)90012-0
Open Access Status Not yet assessed
Volume 70
Issue 3
Start page 301
End page 312
Total pages 12
Place of publication Amsterdam, Netherlands
Publisher Elsevier
Language eng
Abstract The interrupter method for measuring respiratory system resistance involves rapidly interrupting flow at the airway opening while measuring the pressure just distal to the site of interruption. In general, the pressure signal obtained exhibits an initial rapid change (ΔPinit) accompanied by rapid damped oscillations, followed by a further slow change to a steady-state plateau level. ΔPinit is thought to principally reflect the resistance of the pulmonary airways Raw. We have developed a computer model capable of simulating the main features observed in an interrupter pressure signal. We show that the distinct phases in the pressure signal can be obscured by the existence of a compliant compartment between the airways and the occluding valve (e.g. the cheeks and pharynx) when Raw is increased. Our results suggest that supporting the cheeks may enable one to estimate Raw with the interrupter technique in the presence of mild to moderate bronchoconstriction, but that with severe bronchoconstriction (Raw increased 10-fold above normal) it may not be possible.
Keyword Physiology
Respiratory System
Respiratory System
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Non-UQ

Document type: Journal Article
Sub-type: Article (original research)
Collection: School of Medicine Publications
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Citation counts: TR Web of Science Citation Count  Cited 44 times in Thomson Reuters Web of Science Article | Citations
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Created: Wed, 17 Nov 2010, 21:17:11 EST