Big ideas for small brains: What can psychiatry learn from worms, flies, bees and fish?

Burne, T. H. J., Scott, E., van Swinderen, B., Hilliard, M., Reinhard, J., Claudianos, C., Eyles, D. W. and McGrath, J. J. (2011) Big ideas for small brains: What can psychiatry learn from worms, flies, bees and fish?. Molecular Psychiatry, 16 1: 7-16. doi:10.1038/mp.2010.35

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Author Burne, T. H. J.
Scott, E.
van Swinderen, B.
Hilliard, M.
Reinhard, J.
Claudianos, C.
Eyles, D. W.
McGrath, J. J.
Title Big ideas for small brains: What can psychiatry learn from worms, flies, bees and fish?
Journal name Molecular Psychiatry   Check publisher's open access policy
ISSN 1359-4184
Publication date 2011-01-01
Year available 2010
Sub-type Article (original research)
DOI 10.1038/mp.2010.35
Open Access Status
Volume 16
Issue 1
Start page 7
End page 16
Total pages 10
Place of publication Basingstoke, England
Publisher Stockton Press
Language eng
Subject 1312 Molecular Biology
2738 Psychiatry and Mental health
2804 Cellular and Molecular Neuroscience
Abstract While the research community has accepted the value of rodent models as informative research platforms, there is less awareness of the utility of other small vertebrate and invertebrate animal models. Neuroscience is increasingly turning to smaller, non-rodent models to understand mechanisms related to neuropsychiatric disorders. Although they can never replace clinical research, there is much to be learnt from 'small brains'. In particular, these species can offer flexible genetic 'tool kits' that can be used to explore the expression and function of candidate genes in different brain regions. Very small animals also offer efficiencies with respect to high-throughput screening programs. This review provides a concise overview of the utility of models based on worm, fruit fly, honeybee and zebrafish. Although these species may have small brains, they offer the neuropsychiatric research community opportunities to explore some of the most important research questions in our field.Molecular Psychiatry advance online publication, 30 March 2010; doi:10.1038/mp.2010.35.
Keyword Animal Model
C. Elegans
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ
Additional Notes Advance online publication 30 March 2010.

Document type: Journal Article
Sub-type: Article (original research)
Collections: Official 2011 Collection
Queensland Brain Institute Publications
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Citation counts: TR Web of Science Citation Count  Cited 34 times in Thomson Reuters Web of Science Article | Citations
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Created: Tue, 16 Nov 2010, 21:47:43 EST by Dr Thomas Burne on behalf of Queensland Brain Institute