A genome-wide association study of Cloninger’s temperament scales: Implications for the evolutionary genetics of personality

Verweij, Kjh, Zietsch, BP, Medland, SE, Gordon, SD, Benyamin, B, Nyholt, DR, McEvoy, BP, Sullivan, PF, Heath, AC, Madden, PAF, Henders, AK, Montgomery, GW, Martin, NG and Wray, NR (2010) A genome-wide association study of Cloninger’s temperament scales: Implications for the evolutionary genetics of personality. Biological Psychology, 85 2: 306-317. doi:10.1016/j.biopsycho.2010.07.018

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Author Verweij, Kjh
Zietsch, BP
Medland, SE
Gordon, SD
Benyamin, B
Nyholt, DR
McEvoy, BP
Sullivan, PF
Heath, AC
Madden, PAF
Henders, AK
Montgomery, GW
Martin, NG
Wray, NR
Title A genome-wide association study of Cloninger’s temperament scales: Implications for the evolutionary genetics of personality
Journal name Biological Psychology   Check publisher's open access policy
ISSN 0301-0511
1873-6246
Publication date 2010-10-01
Year available 2010
Sub-type Article (original research)
DOI 10.1016/j.biopsycho.2010.07.018
Open Access Status DOI
Volume 85
Issue 2
Start page 306
End page 317
Total pages 12
Place of publication Amsterdam, Netherlands
Publisher Elsevier
Language eng
Subject 1701 Psychology
1702 Cognitive Sciences
Formatted abstract
Variation in personality traits is 30-60% attributed to genetic influences. Attempts to unravel these genetic influences at the molecular level have, so far, been inconclusive. We performed the first genome-wide association study of Cloninger's temperament scales in a sample of 5117 individuals, in order to identify common genetic variants underlying variation in personality. Participants' scores on Harm Avoidance, Novelty Seeking, Reward Dependence, and Persistence were tested for association with 1,252,387 genetic markers. We also performed gene-based association tests and biological pathway analyses. No genetic variants that significantly contribute to personality variation were identified, while our sample provides over 90% power to detect variants that explain only 1% of the trait variance. This indicates that individual common genetic variants of this size or greater do not contribute to personality trait variation, which has important implications regarding the genetic architecture of personality and the evolutionary mechanisms by which heritable variation is maintained. (c) 2010 Elsevier B.V. All rights reserved.
Keyword Evolution
Genes
Genome-wide association
Maintenance of genetic variation
Mutation
Personality
Selection
Temperament
Q-Index Code C1
Q-Index Status Confirmed Code
Grant ID 241944
QLG2-CT-2002-01254
AA07535
480-05-003
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: Official 2011 Collection
School of Medicine Publications
School of Psychology Publications
 
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Created: Tue, 16 Nov 2010, 21:19:57 EST by Mr Brendan Zietsch on behalf of School of Psychology