Regulation of inducible BALT formation and contribution to immunity and pathology

Foo, S. Y. and Phipps, S. (2010) Regulation of inducible BALT formation and contribution to immunity and pathology. Mucosal Immunology, 3 6: 537-544. doi:10.1038/mi.2010.52

Author Foo, S. Y.
Phipps, S.
Title Regulation of inducible BALT formation and contribution to immunity and pathology
Journal name Mucosal Immunology   Check publisher's open access policy
ISSN 1933-0219
Publication date 2010-11-01
Year available 2010
Sub-type Article (original research)
DOI 10.1038/mi.2010.52
Open Access Status Not yet assessed
Volume 3
Issue 6
Start page 537
End page 544
Total pages 8
Place of publication New York, NY, United States
Publisher Nature Publishing Group
Language eng
Abstract Inducible bronchus-associated lymphoid tissue (iBALT) is an organized tertiary lymphoid structure that is not pre-programmed but develops in response to infection or under chronic inflammatory conditions. Emerging research has shown that iBALT provides a niche for T-cell priming and B-cell education to assist in the clearance of infectious agents, highlighting the prospect that iBALT may be engineered and harnessed to enhance protective immunity against respiratory pathogens. Although iBALT formation is associated with several canonical factors of secondary lymphoid organogenesis such as lymphotoxin-α and the homeostatic chemokines, CXCL13, CCL19, and CCL21, these cytokines are not mandatory for its formation, even though they influence its organization and function. Similarly, lymphoid tissue-inducer cells are not a requisite of iBALT formation. In contrast, dendritic cells are emerging as pivotal players required to form and sustain the presence of iBALT. Regulatory T cells appear to be able to attenuate the development of iBALT, although the underlying mechanisms remain ill-defined. In this review, we discuss facets unique to iBALT induction, the cellular subsets, and molecular cues that govern this process, and the contribution of this ectopic structure toward the generation of immune responses in the pulmonary compartment. © 2010 Society for Mucosal Immunology.
Keyword Immunoglobulin E
Pattern recognition receptor
Adoptive transfer
Cell population
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: Official 2011 Collection
School of Biomedical Sciences Publications
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Created: Sun, 07 Nov 2010, 10:04:16 EST