Monoclonal immunoglobulin bands in the cerebrospinal fluid

McCombe, P. A., Brown, N. N., Barr, A. E. and Parkin, L. (1991) Monoclonal immunoglobulin bands in the cerebrospinal fluid. Australian and New Zealand Journal of Medicine, 21 2: 227-229. doi:10.1111/j.1445-5994.1991.tb00447.x

Author McCombe, P. A.
Brown, N. N.
Barr, A. E.
Parkin, L.
Title Monoclonal immunoglobulin bands in the cerebrospinal fluid
Journal name Australian and New Zealand Journal of Medicine   Check publisher's open access policy
ISSN 0004-8291
Publication date 1991-04-01
Sub-type Article (original research)
DOI 10.1111/j.1445-5994.1991.tb00447.x
Open Access Status Not Open Access
Volume 21
Issue 2
Start page 227
End page 229
Total pages 3
Place of publication Richmond, Vic., Australia
Publisher Wiley-Blackwell Publishing Asia
Language eng
Abstract Isoelectric focusing and immunofixation allow the detection of abnormal immunoglobulin bands in the cerebrospinal fluid (CSF). In normal subjects, the immunoglobulins in the CSF are derived from serum. In inflammatory disorders of the nervous system, there may be intrathecal immunoglobulin synthesis usually seen as oligoclonal bands confined to the CSF. Monoclonal immunoglobulin bands in the CSF are not common. We surveyed 1490 CSF samples, and found that a total of nine had a monoclonal immunoglobulin band and that in three this was not present in the serum. Of these three, one patient had chronic inflammatory demyelinating polyneuropathy and the antibody may have been secreted by lymphocytes which had infiltrated the nervous system. The other patients had either lymphoma or lymphomatoid granulomatosis within or adjacent to the nervous system and the monoclonal immunoglobulin was probably secreted by B lymphocytes within those lesions.
Keyword CSF
Lymphomatoid granulomatosis
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collection: School of Medicine Publications
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